Longitudinal comparison of HIV-1 plasma viral load and cellular proviral load
| Autor: | Monika Timmen-Wego, Rolf Kaiser, Björn Jensen, Gerd Fätkenheuer, Finja Schweitzer, Visa H Mikkola |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
business.industry Public Health Environmental and Occupational Health Human immunodeficiency virus (HIV) medicine.disease_cause Peripheral blood mononuclear cell Gastroenterology Plasma viral load Infectious Diseases medicine.anatomical_structure Poster Sessions – Abstract P137 Internal medicine White blood cell Immunology Mann–Whitney U test Antiretroviral treatment Medicine In patient Clinical significance business |
| Zdroj: | Journal of the International AIDS Society |
| ISSN: | 1758-2652 |
| Popis: | Introduction : The goal of antiretroviral treatment (ART) in HIV-1 infection is the permanent suppression of plasma viral load (pVL) below the currently existing limit of detection of 50 copies/mL (DAIG HIV-therapy guidelines). Therefore, treatment effectiveness is based on pVL. pVL measurements however do not give any information about the viral reservoir in peripheral blood mononuclear cells (PBMCs). Therefore, the proviral DNA of HIV-1 could be a useful marker for the investigation of viral reservoirs and monitoring ART in patients showing undetectable pVL. Materials and Methods : Seventy-seven treatment-experienced HIV-1 infected patients with pVL |
| Databáze: | OpenAIRE |
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