Pathologists at the Leading Edge of Optimizing the Tumor Tissue Journey for Diagnostic Accuracy and Molecular Testing
| Autor: | David G. Hicks, Luis E. De Las Casas |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Diagnostic accuracy Medical Oncology Pathologist Molecular testing Tissue procurement 03 medical and health sciences 0302 clinical medicine Neoplasms Diagnosis Clinical information Biomarkers Tumor medicine Humans Medical physics Sampling (medicine) Pathology Molecular Medical diagnosis Sampling Review Articles Tumor tissue journey business.industry Diagnostic test General Medicine Tumor tissue Pathologists 030104 developmental biology Molecular Diagnostic Techniques 030220 oncology & carcinogenesis Treatment decision making business AcademicSubjects/MED00690 |
| Zdroj: | American Journal of Clinical Pathology |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1093/ajcp/aqaa212 |
| Popis: | Objectives Tumor biomarker analyses accompanying immuno-oncology therapies are coupled with a tumor tissue journey aiming to guide tissue procurement and allow for accurate diagnosis and delivery of test results. The engagement of pathologists in the tumor tissue journey is essential because they are able to link the preanalytic requirements of this process with pathologic evaluation and clinical information, ultimately influencing treatment decisions for patients with cancer. The aim of this review is to provide suggestions on how cancer diagnosis and the delivery of molecular test results may be optimized, based on the needs and available resources of institutions, by placing the tumor tissue journey under the leadership of pathologists. Methods Literature searches on PubMed and personal experience provided the necessary material to satisfy the objectives of this review. Results Pathologists are usually involved across many steps of the tumor tissue journey and have the requisite knowledge to ensure its efficiency. Conclusions The expansion of oncology diagnostic testing emphasizes the need for pathologists to acquire a leadership role in the multidisciplinary effort to optimize the accuracy, completeness, and delivery of diagnoses guiding personalized treatments. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|