Split‐dose versus day‐before regimen of sodium picosulfate plus magnesium citrate for bowel cleansing before colonoscopy in children: Randomized controlled trial

Autor: Giovanni Di Nardo, Enrico Felici, Letizia Zenzeri, Maurizio Mennini, Melania Evangelisti, Pasquale Parisi, Anna Claudia Massolo, Cesare Hassan, Marisa Piccirillo, Livia Lucchini, Silvia Furio, Giovanna Quatrale, Caterina Strisciuglio
Rok vydání: 2023
Předmět:
Zdroj: Digestive Endoscopy.
ISSN: 1443-1661
0915-5635
DOI: 10.1111/den.14481
Popis: polyethylene glycol (PEG) split dose regimen is recommended as the option of choice for colon preparation before colonoscopy in children and adults. Sodium picosulfate plus magnesium citrate (PMC) is equally effective but better tolerated of PEG for bowel preparation before colonoscopy in children. The aim of this study was to assess the superiority of PMC split-dose regimen compared with PMC day-before regimen for bowel cleansing before colonoscopy in children.This was a multicenter, randomized, single-blind study. Pediatric inpatients undergoing colonoscopy received PMC either in the day-before dosing or in split dosing. Overall bowel cleansing was assessed using the Boston Bowel Preparation Scale (BBPS) and was rated as successful when BBPS was ≥ 6. Patient tolerability, acceptability and compliance were recorded.The rate of successful cleansing level was significantly higher in the split-dose group than in the day-before group (P0.001). The BBPS scores were significantly higher in the split-dose group than in the day-before group for the whole colon (P0.001), the right colon (P0.001) and transverse colon (P0,001). Patient acceptability and compliance was better in the split-dose group (P=0.0003; P=0.005). The percentage of children needing nasogastric tube placement was better in the split-dose group (P=0.007).The split-dose regimen of PMC was superior to the day-before regimen in terms of successful colon cleansing and acceptability.
Databáze: OpenAIRE
Externí odkaz: