Declining trend of Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant alleles after the withdrawal of Sulfadoxine-Pyrimethamine in North Western Ethiopia
| Autor: | Adugna Woyessa, Amha Kebede, Geremew Tasew Guma, Gemechu Tadesse Leta, Sofonias K. Tessema, Hussein Mohammed, Beyene Petros, Moges Kassa |
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| Rok vydání: | 2015 |
| Předmět: |
Sulfadoxine
medicine.medical_treatment Plasmodium falciparum lcsh:Medicine DHPS Biology Lumefantrine Antimalarials chemistry.chemical_compound parasitic diseases medicine Animals Artemether Malaria Falciparum lcsh:Science Alleles Dihydropteroate Synthase Multidisciplinary lcsh:R medicine.disease Virology Sulfadoxine/pyrimethamine Drug Combinations Tetrahydrofolate Dehydrogenase Pyrimethamine chemistry Mutation lcsh:Q Ethiopia Dihydropteroate synthase Malaria Research Article medicine.drug |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 10, p e0126943 (2015) |
| ISSN: | 1932-6203 |
| Popis: | Antimalarial drug resistance is one of the major challenges in global efforts of malaria control and elimination. In 1998, chloroquine was abandoned and replaced with sulfadoxine/pyrimethamine, which in turn was replaced with artemether/lumefantrine for the treatment of uncomplicated falciparum malaria in 2004. Sulfadoxine/pyrimethamine resistance is associated with mutations in dihydrofolate reductase (Pfdhfr) and dihydropteroate synthase (Pfdhps) genes. The prevalence of mutation in Pfdhfr and Pfdhps genes were evaluated and compared for a total of 159 isolates collected in two different time points, 2005 and 2007/08, from Pawe hospital, in North Western Ethiopia. The frequency of triple Pfdhfr mutation decreased significantly from 50.8% (32/63) to 15.9% (10/63) (P |
| Databáze: | OpenAIRE |
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