Yersinia pseudotuberculosis Exploits CD209 Receptors for Promoting Host Dissemination and Infection
| Autor: | Xiao Ling Ying, Biao Kan, Hong Ping Huang, Chae Gyu Park, Huai Qi Jing, Kun Yang, Qiao Li, Shi Yun Chen, Shusheng Zhang, John Mambwe Tembo, Yang Xin Fu, Yin Lv, Cheng Lin Ye, Ruifu Yang, Tie Chen, Guo Xing Zheng, Pei Zhang, Hong Hui Ding, Lian Xu Xia, Xin Wang, John D. Klena, Li Wei, Hua Peng, An Yi Li, Mikael Skurnik, Ying Xia He, Lingyu Jiang, Bing Cheng |
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| Přispěvatelé: | Helsinki One Health (HOH), Mikael Skurnik / Principal Investigator, HUSLAB, Department of Bacteriology and Immunology, Medicum, University of Helsinki |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
OUTER-MEMBRANE PROTEIN Lipopolysaccharide 030106 microbiology Immunology LPS core RFB GENE-CLUSTER Spleen DUAL RNA-SEQ DC-SIGN DENDRITIC CELLS Microbiology dissemination DCs O-ANTIGEN 03 medical and health sciences chemistry.chemical_compound SIGN-R1 medicine Yersinia pseudotuberculosis Mesenteric lymph nodes Pathogen Infectivity lipopolysaccharide core Host Response and Inflammation biology integumentary system biology.organism_classification Small intestine 3. Good health CD209b CD209a 030104 developmental biology Infectious Diseases medicine.anatomical_structure chemistry ESCHERICHIA-COLI biology.protein Parasitology NEISSERIA-GONORRHOEAE 3111 Biomedicine NONINTEGRIN CD209 |
| Popis: | Yersinia pseudotuberculosis is a Gram-negative enteropathogen and causes gastrointestinal infections. It disseminates from gut to mesenteric lymph nodes (MLNs), spleen, and liver of infected humans and animals. Although the molecular mechanisms for dissemination and infection are unclear, many Gram-negative enteropathogens presumably invade the small intestine via Peyer's patches to initiate dissemination. In this study, we demonstrate that Y. pseudotuberculosis utilizes its lipopolysaccharide (LPS) core to interact with CD209 receptors, leading to invasion of human dendritic cells (DCs) and murine macrophages. These Y. pseudotuberculosis CD209 interactions result in bacterial dissemination to MLNs, spleens, and livers of both wild-type and Peyer's patch-deficient mice. The blocking of the Y. pseudotuberculosis CD209 interactions by expression of 0-antigen and with oligosaccharides reduces infectivity. Based on the well-documented studies in which HIV-CD209 interaction leads to viral dissemination, we therefore propose an infection route for Y. pseudotuberculosis where this pathogen, after penetrating the intestinal mucosal membrane, hijacks the Y. pseudotuberculosis CD209 interaction antigen-presenting cells to reach their target destinations, MLNs, spleens, and livers. |
| Databáze: | OpenAIRE |
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