From the exposome to mechanistic understanding of chemical-induced adverse effects
| Autor: | Martin Krauss, Irina Lehmann, Benno Schwikowski, Alexander Böhme, David H. Phillips, Tobias Polte, Yu Mei Tan, Michaela Hein, Stefan Scholz, Annika Jahnke, John F. Wambaugh, Werner Brack, Wibke Busch, Till Luckenbach, Thomas Hartung, James J. Galligan, Natàlia Garcia-Reyero, Andrea Müller, Marc Chadeau-Hyam, Rolf Altenburger, Gary W. Miller, Adolf Eisenträger, Achim Aigner, Beate I. Escher, Adrian Covaci, Saskia Trump, Susanne Walter-Rohde, Thorsten Reemtsma, Jörg Hackermüller, Stephanie K. Bopp, Ulrike Rolle-Kampczyk, Gerrit Schüürmann, Gunda Herberth, Marja H. Lamoree, Nils Klüver, Jos C. S. Kleinjans |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
SAFETY ASSESSMENT 010501 environmental sciences 01 natural sciences Human health Environmental Science(all) Adverse Outcome Pathway Systems chemistry EFFECT-DIRECTED ANALYSIS lcsh:Environmental sciences General Environmental Science Risk assessment lcsh:GE1-350 ORGANIC MICROPOLLUTANTS Ecology GENE-EXPRESSION DATA Systems toxicology Chemistry Exposome Risk analysis (engineering) PERFLUORINATED COMPOUNDS Environmental Pollutants HUMAN HAZARD CHARACTERIZATION Systems biology Life Sciences & Biomedicine OUTCOME PATHWAYS Adverse outcomes Environmental Sciences & Ecology Biology Article 03 medical and health sciences SDG 3 - Good Health and Well-being MD Multidisciplinary Animals Humans Adverse effect AOP 0105 earth and related environmental sciences Science & Technology Stressor Environmental Exposure ENVIRONMENTAL RISK-ASSESSMENT 030104 developmental biology Biological target INTEGRATED TESTING STRATEGIES Environmental Sciences |
| Zdroj: | Escher, B I, Hackermüller, J, Polte, T, Scholz, S, Aigner, A, Altenburger, R, Böhme, A, Bopp, S K, Brack, W, Busch, W, Chadeau-Hyam, M, Covaci, A, Eisenträger, A, Galligan, J J, Garcia-Reyero, N, Hartung, T, Hein, M, Herberth, G, Jahnke, A, Kleinjans, J, Klüver, N, Krauss, M, Lamoree, M, Lehmann, I, Luckenbach, T, Miller, G W, Müller, A, Phillips, D H, Reemtsma, T, Rolle-Kampczyk, U, Schüürmann, G, Schwikowski, B, Tan, Y M, Trump, S, Walter-Rohde, S & Wambaugh, J F 2017, ' From the exposome to mechanistic understanding of chemical-induced adverse effects ', Environment International, vol. 99, pp. 97-106 . https://doi.org/10.1016/j.envint.2016.11.029 Escher, B I, Hackermüller, J, Polte, T, Scholz, S, Aigner, A, Altenburger, R, Böhme, A, Bopp, S K, Brack, W, Busch, W, Chadeau-Hyam, M, Covaci, A, Eisenträger, A, Galligan, J J, Garcia-Reyero, N, Hartung, T, Hein, M, Herberth, G, Jahnke, A, Kleinjans, J, Klüver, N, Krauss, M, Lamoree, M, Lehmann, I, Luckenbach, T, Miller, G W, Müller, A, Phillips, D H, Reemtsma, T, Rolle-Kampczyk, U, Schüürmann, G, Schwikowski, B, Tan, Y-M, Trump, S, Walter-Rohde, S & Wambaugh, J F 2016, ' From the exposome to mechanistic understanding of chemical-induced adverse effects ', Environment International . https://doi.org/10.1016/j.envint.2016.11.029 Environment International, Vol 99, Iss, Pp 97-106 (2017) Environment international |
| ISSN: | 0160-4120 |
| Popis: | The exposome encompasses an individual's exposure to exogenous chemicals, as well as endogenous chemicals that are produced or altered in response to external stressors. While the exposome concept has been established for human health, its principles can be extended to include broader ecological issues. The assessment of exposure is tightly interlinked with hazard assessment. Here, we explore if mechanistic understanding of the causal links between exposure and adverse effects on human health and the environment can be improved by integrating the exposome approach with the adverse outcome pathway (AOP) concept that structures and organizes the sequence of biological events from an initial molecular interaction of a chemical with a biological target to an adverse outcome. Complementing exposome research with the AOP concept may facilitate a mechanistic understanding of stress-induced adverse effects, examine the relative contributions from various components of the exposome, determine the primary risk drivers in complex mixtures, and promote an integrative assessment of chemical risks for both human and environmental health. Keywords: Exposome, AOP, Systems toxicology, Systems biology, Systems chemistry, Risk assessment |
| Databáze: | OpenAIRE |
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