Serum and renal IGF-I levels after uninephrectomy in the rat
| Autor: | Geoffrey Boner, M. Davidowitz, Arie Erman, J. Shohat, A. Silbergeld |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Renal Hypertrophy medicine.medical_treatment Kidney Glomerulus Clinical Biochemistry Kidney Nephrectomy Muscle hypertrophy Rats Sprague-Dawley Internal medicine medicine Animals Insulin-Like Growth Factor I business.industry Remnant kidney Insulin Hypertrophy General Medicine Rats Endocrinology medicine.anatomical_structure Compensatory hypertrophy business Glomerular Filtration Rate |
| Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 57:167-173 |
| ISSN: | 1502-7686 0036-5513 |
| DOI: | 10.1080/00365519709056385 |
| Popis: | The hypertrophy of the remaining kidney following uninephrectomy (UNx) has been related to an increase in renal insulin growth factor-I (IGF-I) content. However, while the increase in renal IGF-I lasts for only days after UNx, renal hypertrophy continues for months. In the present study we investigated whether IGF-I also plays a role in the late post uninephrectomy growth of the remaining kidney. Renal IGF-I in the remnant kidney was greater than that of control kidneys (78.3 +/- 17.3 vs 56.0 +/- 14.0 pmol g-1; p0.05) 3 days after UNx, tended to remain higher 30 days after UNx (83.8 +/- 23.6 vs 57.3 +/- 14.5 pmol g-1; p = 0.07), but was similar to that of the control kidney when examined 60 days after UNx (66.6 +/- 15.6 vs. 70.4 +/- 6.7 pmol g-1). Serum IGF-I in uninephrectomized rats was similar to that of controls 3 days after UNx, started to increase above the control level at day 10 after UNx and remained higher 30 and 60 days after UNx (75.9 +/- 6.9 vs. 48.7 +/- 7.3 nmol l-1 at 30 days, and 81.2 +/- 13.7 vs 52.9 +/- 11.0 nmol l-1 at day 60, p0.05 for both). The kidney weight of uninephrectomized rats was higher by 21% than that of controls 3 days after UNx, by 45% 30 days after UNx and by 63% 60 days after UNx (p0.05 for all three observations). At the end of the study, the glomerular volume of uninephrectomized rats was higher by 36% than that of the controls (p0.05) We suggest that in the rat, while the initial post uninephrectomy hypertrophy of the remnant kidney is associated with and most probably mediated by an increase in renal IGF-I, the hypertrophy that persists in later post UNx periods is associated with and may be mediated by an increase in serum IGF-I. |
| Databáze: | OpenAIRE |
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