Insights from the Menstrual Cycle in Pulmonary Arterial Hypertension

Autor:	Mark S. Dooner, Thomas Walsh, Margaret R. MacLean, Athena Poppas, Jason M. Aliotta, Elizabeth O. Harrington, Melissa Allahua, Corey E. Ventetuolo, Grayson L. Baird, Christopher J Mullin, Alexander S. Brodsky, James R. Klinger, Mandy Pereira, Nina Denver, Mary Whittenhall, Ruth Andrew, Ghada Bourjeily
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Pulmonary and Respiratory Medicine RM 2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) media_common.quotation_subject Physiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dehydroepiandrosterone sulfate medicine Humans 030212 general & internal medicine Gonadal Steroid Hormones Menstrual cycle Menstrual Cycle media_common Original Research Pulmonary Arterial Hypertension business.industry medicine.disease Pulmonary hypertension 030228 respiratory system chemistry Observational study Female business Hormone
Zdroj:	Ann Am Thorac Soc
ISSN:	2325-6621
Popis:	Rationale: Sex hormones play a role in pulmonary arterial hypertension (PAH), but the menstrual cycle has never been studied. Objectives: We conducted a prospective observational study of eight women with stable PAH and 20 healthy controls over one cycle. Methods: Participants completed four study visits 1 week apart starting on the first day of menstruation. Relationships between sex hormones, hormone metabolites, and extracellular vesicle microRNA (miRNA) expression and clinical markers were compared with generalized linear mixed modeling. Results: Women with PAH had higher but less variable estradiol (E2) levels (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a644ae9a71af0bcde91e54175033719 https://europepmc.org/articles/PMC7869782/ Zobrazit plný text záznamu