Initial Characterization of the SAFIR Prototype PET-MR Scanner
| Autor: | Bruno Weber, Ilaria Sacco, Agnieszka Zagozdzinska-Bochenek, Peter Fischer, V. Commichau, Geoffrey Warnock, Markus Rudin, Jan Debus, Günther Dissertori, L. Djambazov, Michael Ritzert, Werner Lustermann, Christian Ritzer, Mikiko Ito, Parisa Khateri, Charalampos Tsoumpas, R. Becker, Alfred Buck, Jannis Fischer, Ulf Roser, Matthias T. Wyss, Afroditi Eleftheriou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Scanner
positron emission tomography (PET)/magnetic resonance (MR) Materials science medicine.diagnostic_test High rate PET business.industry Point source preclinical PET insert SAFIR Detector TOF-PET molecular imaging Atomic and Molecular Physics and Optics Coincidence multimodality imaging Full width at half maximum Optics Silicon photomultiplier Analog signal Positron emission tomography medicine Radiology Nuclear Medicine and imaging instrumentation business Instrumentation |
| Zdroj: | IEEE Transactions on Radiation and Plasma Medical Sciences, 4 (5) |
| ISSN: | 2469-7311 |
| Popis: | The SAFIR collaboration is currently developing a high-rate positron emission tomography (PET) insert to study fast kinetic processes in small animals. Our insert is designed for simultaneous image acquisition with a preclinical 7 T magnetic resonance (MR) imaging device. In contrast to existing preclinical PET scanners and inserts, our hardware is optimized for high-rate measurements with source activities up to 500 MBq. As a first step, the SAFIR Prototype insert was constructed. This already incorporates the final components, but has a reduced axial field-of-view (35.6 mm). We use lutetiumyttrium oxyorthosilicate crystals (2.12 mm × 2.12 mm × 13 mm) one-to-one coupled to silicon photomultipliers. All analog signals are digitized within the insert. We use 49 MR-compatible dc- dc converters in the insert to provide the power to all readout electronics. After shimming, no degradation of the homogeneity of the static B0 field in the MR scanner was observed. During full operation, we saw a minor reduction in the signal-to-noise ratio of the MR data of 4.9%. With a low activity point source (22Na 0.65 MBq) we obtained a coincidence energy resolution of 13.8% full width at half maximum (FWhM) and a coincidence timing resolution of 194 ps (FWhM). First PET/MR rat brain and high-rate mouse cardiac images (84.9 MBq) are shown in this article. IEEE Transactions on Radiation and Plasma Medical Sciences, 4 (5) ISSN:2469-7311 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|