Supramolecular co-encapsulation of a photosensitizer and chemotherapeutic drug in cucurbit[8]uril for potential chemophototherapy

Autor:	Fresia Solis-Egaña, Nicole Lavín-Urqueta, Daniel Guerra Díaz, Nory Mariño-Ocampo, Mario A. Faúndez, Denis Fuentealba
Rok vydání:	2021
Předmět:	Bridged-Ring Compounds Macrocyclic Compounds Photosensitizing Agents Imidazoles Antineoplastic Agents Physical and Theoretical Chemistry Imidazolidines Heterocyclic Compounds 2-Ring
Zdroj:	Photochemicalphotobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 21(3)
ISSN:	1474-9092
Popis:	Supramolecular strategies as well as combinatorial approaches have been proposed to improve cancer therapeutics. In this work, we investigated the encapsulation of the photosensitizer acridine orange (AO) and the chemotherapeutic drug oxaliplatin (OxPt) in cucurbit[8]uril (CB[8]), and tested their effect both separate and combined on tumoral cells cultivated in vitro. Binding constants and enthalpies of reaction for the AO@CB[8], (AO)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5e7aba09d4dec4506903f2e7347b35 https://pubmed.ncbi.nlm.nih.gov/35088367 Zobrazit plný text záznamu Full text from SpringerLink