Glucocorticoid regulates secretion of epidermal growth factor in the human salivary gland adenocarcinoma cell line
| Autor: | M. Ota, S. Kyakumoto, R. Kurokawa |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Submandibular Gland Adenocarcinoma Adenocarcinoma Biology Triamcinolone Acetonide Cell Line chemistry.chemical_compound Endocrinology Epidermal growth factor Internal medicine Tumor Cells Cultured medicine Humans Secretion Epidermal Growth Factor DNA synthesis DNA Neoplasm Salivary Gland Neoplasms Submandibular Gland Neoplasms Steroid hormone chemistry Cell culture Salivary Gland Adenocarcinoma Growth inhibition |
| Zdroj: | Journal of Endocrinology. 116:451-455 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1677/joe.0.1160451 |
| Popis: | The treatment of a human submandibular gland adenocarcinoma cell line (HSG cell line) for 48 h with triamcinolone acetonide (TA; 1–100 nmol/l) reduced the secretion of epidermal growth factor (EGF) in a closely related manner to a maximum of 66%. The reduction in the level of EGF secreted resulted in the suppression of DNA synthesis in the HSG cells to a similar extent. When the cells were incubated with TA and exogenous human EGF (hEGF), DNA synthesis was 1·7-fold higher than that without added hEGF. The removal of EGF by the addition of hEGF antibody reduced DNA synthesis in HSG cell cultures to the same extent as did TA. These results suggest that the growth inhibition of HSG cells by TA is due to the reduction in the amount of EGF secreted. J. Endocr. (1988) 116, 451–455 |
| Databáze: | OpenAIRE |
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