Atrial nitroso-redox balance and refractoriness following on-pump cardiac surgery: a randomized trial of atorvastatin
| Autor: | Ricardo Carnicer, Andrea K Roalfe, Yaver Bashir, Michael Hill, Ravi DeSilva, Chandana Ratnatunga, Svetlana Reilly, Mario Petrou, Rana Sayeed, Nikhil Pal, Raja Jayaram, M. Jones, Barbara Casadei, Jillian N. Simon, Keshav Nahar, Keith M. Channon, N Goodfellow, Mark J. Crabtree, Timothy R. Betts |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Time Factors
Refractory Period Electrophysiological Physiology Atorvastatin Action Potentials Atrial Function Right Systemic inflammation law.invention chemistry.chemical_compound law Heart Rate Superoxides Atrial Fibrillation AcademicSubjects/MED00200 Cardiopulmonary Bypass biology Atrial fibrillation Cardiac surgery Clinical trial Treatment Outcome England Cardiology cardiovascular system medicine.symptom Clinical Track Articles Cardiology and Cardiovascular Medicine Oxidation-Reduction medicine.drug Nitroso Compounds medicine.medical_specialty Biopterin Ischaemia-Reperfusion Injury Postoperative Atrial fibrillation Double-Blind Method Physiology (medical) Internal medicine Cardiopulmonary bypass medicine Humans Heart Atria Cardiac Surgical Procedures Atrial refractory period business.industry NADPH Oxidases Perioperative Original Articles medicine.disease Troponin chemistry biology.protein Nitric Oxide Synthase Oxidant stress business |
| Zdroj: | Cardiovascular Research |
| ISSN: | 1755-3245 0008-6363 |
| Popis: | Aims Systemic inflammation and increased activity of atrial NOX2-containing NADPH oxidases have been associated with the new onset of atrial fibrillation (AF) after cardiac surgery. In addition to lowering LDL-cholesterol, statins exert rapid anti-inflammatory and antioxidant effects, the clinical significance of which remains controversial. Methods and results We first assessed the impact of cardiac surgery and cardiopulmonary bypass (CPB) on atrial nitroso-redox balance by measuring NO synthase (NOS) and GTP cyclohydrolase-1 (GCH-1) activity, biopterin content, and superoxide production in paired samples of the right atrial appendage obtained before (PRE) and after CPB and reperfusion (POST) in 116 patients. The effect of perioperative treatment with atorvastatin (80 mg once daily) on these parameters, blood biomarkers, and the post-operative atrial effective refractory period (AERP) was then evaluated in a randomized, double-blind, placebo-controlled study in 80 patients undergoing cardiac surgery on CPB. CPB and reperfusion led to a significant increase in atrial superoxide production (74% CI 71–76%, n = 46 paired samples, P Graphical Abstract |
| Databáze: | OpenAIRE |
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