The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission
| Autor: | Yoav Shulman, Herman Wolosker, Dina Rosenberg, Samah Neame, Salman Zubedat, Simone Engelender, Hazem Safory, Jackie Schiller, Avi Avital, Swen Hülsmann, Inna Radzishevsky, Hagit Sason |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
endocrine system Hypoglossal Nerve Amino Acid Transport System y+ Genotype Glycine Biology Biochemistry Synaptic Transmission Serine 03 medical and health sciences Mice 0302 clinical medicine Receptors Glycine Internal medicine Genetics medicine Animals Metabolomics Hyperekplexia Amino acid transporter Molecular Biology Glycine receptor 030304 developmental biology Mice Knockout Neurons 0303 health sciences Scientific Reports Brain Transporter Biological Transport 3. Good health Endocrinology Phenotype Knockout mouse Mutation Metabolome medicine.symptom 030217 neurology & neurosurgery Cysteine |
| Zdroj: | EMBO reports. 16(5) |
| ISSN: | 1469-3178 |
| Popis: | Asc-1 (SLC7A10) is an amino acid transporter whose deletion causes neurological abnormalities and early postnatal death in mice. Using metabolomics and behavioral and electrophysiological methods, we demonstrate that Asc-1 knockout mice display a marked decrease in glycine levels in the brain and spinal cord along with impairment of glycinergic inhibitory transmission, and a hyperekplexia-like phenotype that is rescued by replenishing brain glycine. Asc-1 works as a glycine and L-serine transporter, and its transport activity is required for the subsequent conversion of L-serine into glycine in vivo. Asc-1 is a novel regulator of glycine metabolism and a candidate for hyperekplexia disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text