EUS-guided single-incision needle-knife biopsy: description and results of a new method for tissue sampling of subepithelial GI tumors (with video)
| Autor: | Pilar Diez-Redondo, Carlos de la Serna-Higuera, Manuel Perez-Miranda, Elena Pérez-Martín, Paula Gil-Simon, Teresa Herranz, C. Ochoa, Agustín Caro-Patón |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Gastrointestinal Stromal Tumors Biopsy Fine-Needle Stomach Diseases Choristoma Retrospective database symbols.namesake Polyps Biopsy Mitotic Index medicine Humans Radiology Nuclear Medicine and imaging Needle knife Pancreas Ultrasonography Interventional Fisher's exact test Aged Gastrointestinal Neoplasms Retrospective Studies Aged 80 and over Leiomyoma medicine.diagnostic_test business.industry Biopsy Needle Gastroenterology Small sample Middle Aged Tissue sampling Immunohistochemistry Surgery Tissue acquisition Single incision symbols Female Lipoma Radiology business |
| Zdroj: | Gastrointestinal Endoscopy. 74:672-676 |
| ISSN: | 0016-5107 |
| Popis: | Background The diagnostic efficacy of current tissue sampling techniques for upper GI subepithelial tumors (SETs) appears to be limited. Better tissue acquisition techniques are needed to improve the diagnostic yield in this setting. Objective Our purpose was to determine the safety and diagnostic yield of EUS-guided needle-knife incision and forceps biopsy (SINK biopsy) of upper GI SETs. Design Retrospective database review. Setting Academic tertiary-care referral center. Patients This study involved 14 consecutive patients referred for EUS evaluation of upper GI SETs with previous unsuccessful attempts at tissue diagnosis by conventional forceps biopsy. Intervention EUS-guided needle-knife incision and forceps biopsy. Main Outcome Measurements The safety and diagnostic yield of this method, compared with EUS-guided fine-needle aspiration (EUS-FNA), when possible. Results SINK biopsy provided tissue samples that were sufficient for definite histologic diagnosis in 13 of 14 cases (diagnostic yield 92.8%). There were 8 gastric GI stromal tumors. In 7 of 8, the size of SINK specimens allowed immunohistochemical analysis, and the evaluation of malignant potential was carried out by means of mitotic index determination in 5 cases (71.42%). SINK biopsies determined the pathological diagnosis of all (4 of 4) nonmesenchymal lesions. Eight patients underwent both EUS-FNA and SINK, with final histologic diagnosis determined in 6 of 8 cases (75%) by SINK versus 1 of 8 cases (12.5%) by EUS-FNA (Fisher exact test, P = .023). There were no procedure-related complications. Limitations A single-center, retrospective analysis with small sample size. Conclusion SINK biopsy appears to be an easy, safe, and effective technique for determining the definitive pathological diagnosis, evaluation of the malignant potential, and planning management of SETs. It could be a reliable alternative to conventional FNA, providing larger samples that improve the histologic yield. |
| Databáze: | OpenAIRE |
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