Poly(rac-lactide) nanocapsules containing diclofenac: protection against muscular damage in rats

Autor:	Gillian Barratt, Francis Puisieux, J.P. Devissaguet, Hatem Fessi, Silvia Stanisçuaski Guterres
Rok vydání:	2000
Předmět:	Male Diclofenac Materials science Polyesters Muscle Fibers Skeletal Biomedical Engineering Biophysics Capsules Bioengineering Pharmacology Benzoates Dosage form Nanocapsules Biomaterials chemistry.chemical_compound medicine Animals Rats Wistar Muscle Skeletal Creatine Kinase Triglycerides Lactide Anti-Inflammatory Agents Non-Steroidal fungi Rats Lactic acid stomatognathic diseases chemistry Connective Tissue Area Under Curve Toxicity Drug carrier Intramuscular injection medicine.drug
Zdroj:	Journal of Biomaterials Science, Polymer Edition. 11:1347-1355
ISSN:	1568-5624 0920-5063
Popis:	The aim of this work was to determine whether encapsulation of a non steroidal antiinflammatory agent within nanocapsules could reduce local toxicity after intramuscular injection. Diclofenac-loaded nanocapsules were prepared by deposition of poly(rac-lactic acid) polymer, and administered intramuscularly to male Wistar rats. Plasma creatine phosphokinase (CPK) activity and histological examination were used to assess local tissue damage. Following a single intramuscular injection of diclofenac (0.8 mg), CPK activity was shown to depend on both the type of dosage form and, in the case of nanocapsules, on the chemical nature of the central oily core. Lower CPK activity was observed with nanocapsules prepared from Miglyol 810, a caprylic/capric triglyceride, while nanocapsules prepared from benzyl benzoate, either empty or containing diclofenac, exhibited the same CPK activity as the drug solution. Histopathological examination performed three days after administration of free diclofenac or nanocapsules containing diclofenac prepared from Miglyol 810 revealed that a much more intense inflammation was obtained with the solution than with nanocapsules. In conclusion, when appropriately formulated, nanocapsules can considerably reduce the muscular damage caused by diclofenac.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a56cf481a1eb89a098206c46a6050f7 https://doi.org/10.1163/156856200744372 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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