Gallium nitride is biocompatible and non-toxic before and after functionalization with peptides
| Autor: | Matthew S. Makowski, Michael J. Manfra, Scott A. Jewett, Albena Ivanisevic, Benjamin Andrews |
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| Rok vydání: | 2011 |
| Předmět: |
Silicon
Materials science Surface Properties Molecular Sequence Data Biomedical Engineering chemistry.chemical_element Nanotechnology Gallium nitride Biocompatible Materials Gallium Biochemistry PC12 Cells Biomaterials chemistry.chemical_compound Animals Amino Acid Sequence Cell adhesion Molecular Biology Aqueous solution Spectrophotometry Atomic fungi technology industry and agriculture General Medicine Adhesion Rats Solutions chemistry Covalent bond Microscopy Electron Scanning Surface modification Chemical stability Peptides Biotechnology |
| Zdroj: | Acta biomaterialia. 8(2) |
| ISSN: | 1878-7568 |
| Popis: | The toxicity of semiconductor materials can significantly hinder their use for in vitro and in vivo applications. Gallium nitride (GaN) is a material with remarkable properties, including excellent chemical stability. This work demonstrated that functionalized and etched GaN surfaces were stable in aqueous environments and leached a negligible amount of Ga in solution even in the presence of hydrogen peroxide. Also, GaN surfaces in cell culture did not interfere with nearby cell growth, and etched GaN promoted the adhesion of cells compared to etched silicon surfaces. A model peptide, "IKVAV", covalently attached to GaN and silicon surfaces increased the adhesion of PC12 cells. Peptide terminated GaN promoted greater cell spreading and extension of neurites. The results suggest that peptide modified GaN is a biocompatible and non-toxic material that can be used to probe chemical and electrical stimuli associated with neural interfaces. |
| Databáze: | OpenAIRE |
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