Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention
| Autor: | Rawya Mohsen, Tommy Cederholm, Bengt Vessby, Eva Warensjö, Ulf Risérus, Inga-Britt Gustafsson |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Fatty Acid Desaturases Male Rapeseed Endocrinology Diabetes and Metabolism Linoleic acid Saturated fat Medicine (miscellaneous) Fatty Acids Monounsaturated Linoleic Acid chemistry.chemical_compound Dietary Fats Unsaturated Humans Plant Oils Food science Aged chemistry.chemical_classification Cross-Over Studies Nutrition and Dietetics Fatty Acids alpha-Linolenic Acid Fatty acid Middle Aged Dietary Fats Crossover study Oleic acid Stearoyl-CoA Desaturase chemistry Biochemistry Female Rapeseed Oil Cardiology and Cardiovascular Medicine Oleic Acid Polyunsaturated fatty acid |
| Zdroj: | Nutrition, Metabolism and Cardiovascular Diseases. 18:683-690 |
| ISSN: | 0939-4753 |
| DOI: | 10.1016/j.numecd.2007.11.002 |
| Popis: | Direct measurement of desaturase activities are difficult to obtain in humans. Consequently, surrogate measures of desaturase activity (estimated desaturase activities) have been frequently used in observational studies, and estimated Delta(9)- (or stearoyl-CoA-desaturase (SCD)), Delta(6)- and Delta(5)-desaturase activities have been associated with cardiometabolic disease. Data on how the markers of desaturase activities are modified by changes in dietary fat quality are lacking and therefore warrant examination.In a two-period (three weeks) strictly controlled cross-over study, 20 subjects (six women and 14 men) consumed a diet high in saturated fat (SAT-diet) and a rapeseed oil diet (RO-diet), rich in oleic acid (OA), linoleic acid (LA) and alpha-linolenic acid (ALA). Estimated desaturase activities were calculated as precursor to product FA ratios in serum cholesteryl esters and phospholipids. The estimated SCD [16:1 n-7/16:0] and Delta(6)-desaturase [20:3 n-6/18:2 n-6] was significantly higher while Delta(5)-desaturase [20:4 n-6/20:3 n-6] was significantly lower in the SAT-diet (P0.001 for all), compared to the RO-diet. The serum proportions of palmitic, stearic, palmitoleic and dihomo-gamma-linolenic acids were significantly higher in the SAT-diet while the proportions of LA and ALA were significantly higher in the RO-diet.This is the first study to demonstrate that surrogate measures of desaturase activities change as a consequence of an alteration in dietary fat quality. Both the [16:1/16:0]-ratio and 16:1 seem to reflect changes in saturated fat intake and may be useful markers of saturated fat intake in Western countries. |
| Databáze: | OpenAIRE |
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