Anti-diabetic and anti-oxidative effects of 4-hydroxypipecolic acid in C57BL/KsJ-db/db mice
| Autor: | J.P. Chaturvedi, Arvind K. Srivastava, Achila Singh, Tadigoppula Narender, Tanvir Khaliq |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment Muscle Fibers Skeletal Mice Transgenic Toxicology Kidney Antioxidants Cell Line Lipid peroxidation chemistry.chemical_compound Mice Peganum harmala Gum acacia Internal medicine Malondialdehyde medicine Animals Hypoglycemic Agents chemistry.chemical_classification Glutathione Peroxidase biology Plant Extracts Superoxide Dismutase Glutathione peroxidase Kidney metabolism Fatty acid General Medicine biology.organism_classification Catalase Lipids Rats Mice Inbred C57BL Endocrinology Glucose chemistry Liver Pipecolic Acids Seeds Peganum Lipid Peroxidation |
| Zdroj: | Humanexperimental toxicology. 31(1) |
| ISSN: | 1477-0903 |
| Popis: | Hypoglycemic effect of ethanol extracts of Peganum harmala (commonly known as 'Harmal') seeds has been reported on normal and streptozotocin-induced diabetic rats. In the present study, the authors determine anti-diabetic and anti-oxidative properties of 4-hydroxypipecolic acid (4-HPA) isolated from seeds of P. harmala in C57BL/KsJ-db/db mice. Twelve week old male mice were administered 50 mg/kg body weight (4-HPA suspension were made in 1% gum acacia) for the period of 10 days, and a significant reduction in the fasting blood glucose, plasma triglycerides (TG), cholesterol, free fatty acid, low-density lipoprotein-cholesterol and a significant increase in high-density lipoprotein-cholesterol level was observed with respect to vehicle-treated db/db mice. The anti-oxidant activity of 4-hydroxypipecolic acid was studied in liver and kidney tissues by assessing malondialdehyde levels for lipid peroxidation and enzyme activity of catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD). Treatment of 4-HPA significantly lowered the lipid peroxidation in hepatic and renal tissue and increased the activity of CAT, GSH-Px and SOD in treated mice. |
| Databáze: | OpenAIRE |
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