Recent MMR vaccination in health care workers and Covid-19: A test negative case-control study
| Autor: | Susannah Leach, Claes Ohlsson, Maria Bygdell, Jenny M. Kindblom, Susanne Woxenius, Gustaf Stukat von Feilitzen, Lisa Lundberg |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty COVID-19 Vaccines Measles-Mumps-Rubella Vaccine Health Personnel Short Communication 030231 tropical medicine MMR vaccine Measles Rubella 03 medical and health sciences 0302 clinical medicine Internal medicine Health care Humans Medicine 030212 general & internal medicine Mumps General Veterinary General Immunology and Microbiology SARS-CoV-2 business.industry Vaccination Public Health Environmental and Occupational Health Case-control study Odds ratio medicine.disease Infectious Diseases Case-Control Studies Molecular Medicine Female Covid-19 business |
| Zdroj: | Vaccine |
| ISSN: | 0264-410X |
| Popis: | Background It has been hypothesised that the measles-mumps-rubella (MMR) vaccine may afford cross-protection against SARS-CoV-2 which may contribute to the wide variability in disease severity of Covid-19. Methods We employed a test negative case-control study, utilising a recent measles outbreak during which many healthcare workers received the MMR vaccine, to investigate the potential protective effect of MMR against SARS-CoV-2 in 5905 subjects (n = 805 males, n = 5100 females). Results The odds ratio for testing positive for SARS-CoV-2, in recently MMR-vaccinated compared to not recently MMR-vaccinated individuals was 0.91 (95% CI 0.76, 1.09). An interaction analysis showed a significant interaction for sex. After sex-stratification, the odds ratio for testing positive for males was 0.43 (95% CI 0.24, 0.79, P = 0.006), and 1.01 (95% CI 0.83, 1.22, P = 0.92) for females. Conclusion Our results indicate that there may be a protective effect of the MMR vaccine against SARS-CoV-2 in males but not females. |
| Databáze: | OpenAIRE |
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