The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the sleep-promoting effects of tryptophan: A randomized placebo-controlled crossover study
| Autor: | C. Rob Markus, Jens H van Dalfsen |
|---|---|
| Přispěvatelé: | Section Psychopharmacology, RS: FPN NPPP II |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Serotonin SYMPTOMS Genotype insomnia Biology Placebo 5-HTTLPR 03 medical and health sciences Young Adult 0302 clinical medicine Double-Blind Method Internal medicine ACTIGRAPHY Sleep Initiation and Maintenance Disorders medicine QUALITY Humans Pharmacology (medical) Allele Gene Serotonin transporter Alleles 030304 developmental biology Pharmacology Serotonin Plasma Membrane Transport Proteins 0303 health sciences Cross-Over Studies Polymorphism Genetic Tryptophan Brain ADULTS ASSOCIATION Crossover study Original Papers FAMILY PREVALENCE Psychiatry and Mental health Endocrinology biology.protein Female PARA-CHLOROPHENYLALANINE Sleep 030217 neurology & neurosurgery |
| Zdroj: | Journal of Psychopharmacology (Oxford, England) Journal of Psychopharmacology, 33(8), 948-954 Journal of Psychopharmacology, 33(8), 948-954. SAGE Publications Ltd |
| ISSN: | 1461-7285 0269-8811 |
| Popis: | Background:The low-expressive short (S) allele of a functional polymorphism (5-HTTLPR) within the serotonin (5-hydroxytriptamine; 5-HT) transporter gene (SLC6A4) has been associated with a reduced functioning of the brain 5-HT system relative to the long (L) allele. As a consequence, the S-allele is found to predispose individuals to a higher risk of sleep quality reduction and clinical insomnia.Aims:The present study investigated whether subchronic pre-sleep tryptophan administration could compensate for this predisposition by improving sleep in 5-HTTLPR S-allele carriers.Methods:In a double-blind placebo-controlled crossover design a sample of homozygous 5-HTTLPR S-allele ( n = 47) and L-allele ( n = 51) carriers were assessed for subjective (sleep diary) and objective (actigraphy) sleep during a treatment protocol consisting of 1 week of placebo (1000 mg/day) and 1 week of tryptophan administration (1000 mg/day).Results:The results support the sleep-promoting effects of tryptophan. Tryptophan improved objective sleep efficiency and objective wake after sleep onset irrespective of allelic variation. There was a marginally significant improvement of subjective sleep quality in the 5-HTTLPR S-allele group but not in the L-allele group following tryptophan relative to placebo intake. In contrast, a significantly poorer sleep quality in the S-allele as opposed to the L-allele group in the placebo condition was not observed in the tryptophan condition.Conclusions:Tryptophan augmentation promises to be a valuable treatment strategy for sleep impairments related to genetic deficiencies in 5-HT functioning. |
| Databáze: | OpenAIRE |
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