Ethnic‐Specific Genetic Associations with Pulmonary Tuberculosis
| Autor: | Julio C. Delgado, Anne E. Goldfeld, Andres Baena, Sok Thim |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Candidate gene Tuberculosis Population Tuberculin Disease Genetic determinism Mycobacterium tuberculosis Polymorphism (computer science) Humans Immunology and Allergy Medicine Genetic Predisposition to Disease education Cation Transport Proteins Tuberculosis Pulmonary education.field_of_study Polymorphism Genetic biology Tumor Necrosis Factor-alpha business.industry medicine.disease biology.organism_classification Interleukin-10 Infectious Diseases Immunology Receptors Calcitriol Female Disease Susceptibility business Interleukin-1 |
| Zdroj: | The Journal of Infectious Diseases. 186:1463-1468 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | �untranslated region, were associated with TB susceptibility and resistance, respectively. Other polymorphisms associated with differential susceptibility to TB were not associated with susceptibility or resistance to TB in Cambodians. The novel pattern of genetic associations with susceptibility and resistance to TB detected in Cambodia is consistent with the conclusion that unique environmental and natural selective factors have resulted in the development of ethnic-specific host genetic factors associated with TB susceptibility and resistance worldwide. Approximately one-third of the world’s population is infected with the bacteria that causes tuberculosis (TB), Mycobacterium tuberculosis. One in 10 of those infected are estimated to progress to active TB disease. Thus, TB is a significant cause of morbidity and mortality and causes ∼2 million deaths annually [1–3]. As early as 1949, Haldane [4] proposed that the maintenance of multiple genes that confer relative susceptibilities on the host to infectious diseases would be favored by evolution. In support of this hypothesis, certain populations appear to be at risk for both increased susceptibility to infection [5] and progressive clinical disease due to mycobacteria [6–9], and several case-control studies have identified associations between TB disease and candidate genes potentially involved in the immune response to TB [10, 11]. |
| Databáze: | OpenAIRE |
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