The role of salivary vesicles as a potential inflammatory biomarker to detect traumatic brain injury in mixed martial artists
| Autor: | Mark S. Dooner, Mandy Pereira, Yan Cheng, Sicheng Wen, Janette Baird, Peter J. Quesenberry, Neha P. Raukar, Rani Matuk, Shyam Rao |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Saliva Traumatic brain injury Science Article Extracellular Vesicles Young Adult 03 medical and health sciences 0302 clinical medicine Brain Injuries Traumatic medicine Humans Gene Regulatory Networks Multidisciplinary Molecular medicine business.industry Mechanism (biology) Gene Expression Profiling Biological techniques Head injury 030229 sport sciences medicine.disease Pathophysiology Gene Expression Regulation Neurology Case-Control Studies Immunology Biomarker (medicine) Medicine Female business Inflammatory biomarker Neurocognitive Biomarkers Martial Arts 030217 neurology & neurosurgery Biotechnology Neuroscience |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Traumatic brain injury (TBI) is of significant concern in the realm of high impact contact sports, including mixed martial arts (MMA). Extracellular vesicles (EVs) travel between the brain and oral cavity and may be isolated from salivary samples as a noninvasive biomarker of TBI. Salivary EVs may highlight acute neurocognitive or neuropathological changes, which may be particularly useful as a biomarker in high impact sports. Pre and post-fight samples of saliva were isolated from 8 MMA fighters and 7 from controls. Real-time PCR of salivary EVs was done using the TaqMan Human Inflammatory array. Gene expression profiles were compared pre-fight to post-fight as well as pre-fight to controls. Largest signals were noted for fighters sustaining a loss by technical knockout (higher impact mechanism of injury) or a full match culminating in referee decision (longer length of fight), while smaller signals were noted for fighters winning by joint or choke submission (lower impact mechanism as well as less time). A correlation was observed between absolute gene information signals and fight related markers of head injury severity. Gene expression was also significantly different in MMA fighters pre-fight compared to controls. Our findings suggest that salivary EVs as a potential biomarker in the acute period following head injury to identify injury severity and can help elucidate pathophysiological processes involved in TBI. |
| Databáze: | OpenAIRE |
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