123I-FP-CIT SPECT in dementia with Lewy bodies, Parkinson’s disease and Alzheimer’s disease: a new quantitative analysis of autopsy confirmed cases
| Autor: | Johannes Attems, Mariana Silva, Francisco P. M. Oliveira, Durval C. Costa, Carla Oliveira, Joana C. Castanheira, Sofia C. Vaz, Rodney W H Walker, Zuzana Walker, Ângelo F. Silva |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Parkinson's disease business.industry Dementia with Lewy bodies Putamen Autopsy Diagnostic accuracy Disease medicine.disease Gastroenterology 030218 nuclear medicine & medical imaging 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine 123I-FP-CIT Internal medicine mental disorders Medicine Surgery Neurology (clinical) business Quantitative analysis (chemistry) 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology, Neurosurgery and Psychiatry, 92(6), 662-667. BMJ PUBLISHING GROUP |
| ISSN: | 1468-330X 0022-3050 |
| DOI: | 10.1136/jnnp-2020-324606 |
| Popis: | PurposeThe aim of this study was to re-evaluate the differentiation of patients with dementia with Lewy bodies (DLB) from Alzheimer’s disease (AD) and Parkinson’s disease (PD) using a quantitative analysis of 123I-FP-CIT SPECT scans.MethodsThirty-six patients with in vivo 123I-FP-CIT SPECT and neuropathological diagnoses were included. Based on neuropathological criteria, patients were further subclassified into nine AD, eight DLB, ten PD and nine with other diagnoses. An additional 16 healthy controls (HC) scanned with 123I-FP-CIT SPECT were also included. All images were visually assessed as normal versus abnormal uptake by consensus of five nuclear medicine physicians. Bihemispheric mean was calculated for caudate binding potential (CBP), putamen binding potential (PBP) and putamen-to-caudate ratio (PCR).ResultsPatients with DLB had significantly lower CBP and PBP than patients with AD and significantly higher PCR than patients with PD. Qualitative visual analysis of the images gave an accuracy of 88% in the evaluation of the status of the nigrostriatal pathway considering all individuals, and 96% considering only the patients with PD, AD and DLB. Quantitative analyses provided a balanced accuracy of 94%, 94% and 100% in binary classifications DLB versus AD, DLB versus PD and PD versus AD, respectively, and an accuracy of 93% in the differentiation among patients with DLB, AD and PD simultaneously. No statistically significant differences were observed between the AD and HC.ConclusionsThis study demonstrates a very high diagnostic accuracy of the quantitative analysis of(123I-FP-CIT SPECT data to differentiate among patients with DLB, PD and AD. |
| Databáze: | OpenAIRE |
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