New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists

Autor:	Adriano Martinelli, Giuseppe Saccomanni, Maria Grazia Cascio, Carla Ghelardini, E. Vivoli, Vincenzo Di Marzo, V. Benetti, Tiziano Tuccinardi, Clementina Manera, Pier Luigi Ferrarini, Marco Allarà
Rok vydání:	2007
Předmět:	Molecular model medicine.drug_class Stereochemistry medicine.medical_treatment Clinical Biochemistry Pharmaceutical Science Carboxamide Biochemistry Chemical synthesis Cell Line Receptor Cannabinoid CB2 Mice chemistry.chemical_compound Receptor Cannabinoid CB1 In vivo Drug Discovery Cannabinoid receptor type 2 medicine Animals Humans Naphthyridines Molecular Biology Pain Measurement Chemistry Organic Chemistry Quinoline CB2 receptor Quinolines Molecular Medicine lipids (amino acids peptides and proteins) Cannabinoid Selectivity
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 17:6505-6510
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2007.09.089
Popis:	A series of new 1,8-naphthyridine and quinoline derivatives were synthesized and evaluated for their cannabinoid receptor affinity. In particular, compounds 2, 5, 11, and 13 showed a high CB2 affinity and CB2 versus CB1 selectivity, in agreement with molecular modeling studies. Furthermore, compound 2 also exhibited in vivo antinociceptive effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a50b5f1fe5fdbd5344324fcd727f450 https://doi.org/10.1016/j.bmcl.2007.09.089 Zobrazit plný text záznamu Full Text from ScienceDirect