Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes
| Autor: | Jacobo Wortsman, Edward T. Wei, Jolanta Mysliwska, Andrzej Mysliwski, Blazej Zbytek, Andrzej Slominski |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Keratinocytes
Lipopolysaccharides endocrine system medicine.medical_specialty Cell Survival Corticotropin-Releasing Hormone medicine.medical_treatment Enzyme-Linked Immunosorbent Assay General Biochemistry Genetics and Molecular Biology Corticotropin-releasing hormone Internal medicine medicine Escherichia coli Humans General Pharmacology Toxicology and Pharmaceutics Receptor Cell Line Transformed Chemistry General Medicine Differential effects HaCaT Endocrinology Cytokine Cell culture Cytokines hormones hormone substitutes and hormone antagonists Function (biology) |
| Zdroj: | Life sciences. 70(9) |
| ISSN: | 0024-3205 |
| Popis: | CRH cutaneous expression is significantly enhanced after exposure to various stimuli (Physiol Rev 2000, 80;979-1020). We evaluated the effect of CRH on cytokine production in HaCaT keratinocytes, a cell line shown to express CRH receptors coupled to cAMP activation and calcium-dependent transmission pathways. It is demonstrated for the first time that exogenously added CRH stimulates production of IL-6 and IL-11. It also inhibits production of IL-1beta and does not affect TNF-alpha production. Our results indicate that CRH function(s) during cutaneous stress may be mediated by differential effects on cytokine production. |
| Databáze: | OpenAIRE |
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