Prognostic value of the C-reactive protein/Albumin Ratio (CAR) in patients with operable soft tissue sarcoma
| Autor: | Yuan Xiang Guan, Yao Liang, Cheng Fang, Xing Zhang, Wei Wang, Zhiwei Zhou, Huo Ying Chen, Wei Xiao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty C-reactive protein 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Stage (cooking) albumin Receiver operating characteristic biology business.industry Proportional hazards model Soft tissue sarcoma inflammation-based prognostic factors Hazard ratio Cancer medicine.disease Confidence interval Surgery 030104 developmental biology 030220 oncology & carcinogenesis soft tissue sarcoma biology.protein prognosis business human activities Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Yao Liang 1, * , Wei Xiao 1, * , Yuan-Xiang Guan 1, * , Wei Wang 1 , Huo Ying Chen 1 , Cheng Fang 1 , Xing Zhang 1 and Zhi-Wei Zhou 1 1 Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, People’s Republic of China * Co-first authors Correspondence to: Zhi-Wei Zhou, email: zhouzhw@sysucc.org.cn Xing Zhang, email: zhangxing@sysucc.org.cn Keywords: C-reactive protein; albumin; inflammation-based prognostic factors; soft tissue sarcoma; prognosis Received: July 19, 2017 Accepted: August 17, 2017 Published: September 18, 2017 ABSTRACT Background: The preoperative C-reactive protein/Albumin ratio (CAR) is valuable for predicting the prognosis of patients with various types of cancers. The aim of the present study is to investigate the prognostic value of the preoperative CAR and compare it with other systemic inflammatory response markers in patients with soft tissue sarcoma (STS). Methods: This retrospective study included 206 patients with STS. The optimal cutoff value of the CAR was determined by receiver operating characteristic (ROC) analysis. The impact of the CAR and other clinicopathological features on overall survival (OS) and disease-free survival (DFS) was evaluated using univariate and multivariate Cox regression analyses. Kaplan-Meier survival analyses were used to compare groups classified by the CAR. Additionally, the area under the receiver operating characteristic curve (AUC) was used to compare the predictive ability of the CAR, high-sensitivity modified Glasgow prognostic score (Hs-mGPS), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR). Results: The optimal cut-off value of the CAR was 0.1035 according to the ROC analysis. An increased CAR (≥0.1035) was significantly associated with older age, larger tumor size, deep tumor location, higher tumor grade and more advanced American Joint Committee on Cancer (AJCC) stage (all P |
| Databáze: | OpenAIRE |
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