Long-term tracking of fasting blood glucose variability and peripheral artery disease in people without diabetes
Autor: | Xin Xue Liao, Xiaodong Zhuang, Cheng Zeng, Yue Guo, Xiu Ting Sun, Da Ya Yang, Zhen Yu Xiong, Hui Min Zhou, Shao Zhao Zhang, Xiang Bin Zhong |
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Rok vydání: | 2020 |
Předmět: |
Blood Glucose
Male Cardiovascular and Metabolic Risk medicine.medical_specialty Arterial disease glucose metabolism Endocrinology Diabetes and Metabolism Coefficient of variation Disease Peripheral Arterial Disease Risk Factors Diabetes mellitus Internal medicine Diabetes Mellitus Humans Medicine Trial registration business.industry Incidence (epidemiology) Fasting medicine.disease cardiovascular disease risk medicine.anatomical_structure Quartile Cardiology Female atherosclerosis Ankle business |
Zdroj: | BMJ Open Diabetes Research & Care |
ISSN: | 2052-4897 |
Popis: | IntroductionLong-term changes of fasting blood glucose (FBG) in relation to lower-extremity peripheral artery disease (lower-extremity PAD) in people without diabetes has barely been reported. Our study aimed to investigate the association between FBG variability and the incidence of lower-extremity PAD in people without diabetes.Research design and methodsWe included 7699 participants without prior lower-extremity PAD and diabetes from the Atherosclerosis Risk in Communities study in the final analysis. At least two measurements of FBG were required during follow-up. Variability of FBG was identified using SD, coefficient of variation (CV), variability independent of the mean (VIM) and average real variability. Lower-extremity PAD was defined as an ankle brachial index ResultsDuring a median follow-up of 19.5 years, 504 (6.5 %) lower-extremity PAD events were observed, 54.4% (n=274) were male, and 17.5% (n=88) were African-American. FBG variability was positively associated with incident lower-extremity PAD, with a linear relationship. HRs for CV and VIM were 1.015 (95% CI: 1.001 to 1.03; p=0.023), and 1.032 (95% CI: 1.004 to 1.06; p=0.022) for lower-extremity PAD, respectively. Participants in the lowest quartile of CV were at lower lower-extremity PAD risk compared with the highest ones (HR: 1.499, 95% CI: 1.16 to 1.938; p=0.002).ConclusionsHigher FBG variability was independently associated with increased prevalence of lower-extremity PAD in people without diabetes.Trial registration numberNCT00005131. |
Databáze: | OpenAIRE |
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