Flow Chemistry Syntheses of Styrenes, Unsymmetrical Stilbenes and Branched Aldehydes
| Autor: | Berthold Schenkel, Paeivi Tolstoy, Samuel L. Bourne, Benjamin Martin, Matthew O'Brien, Roderick W. Bates, Sivarajan Kasinathan, Dennis X. Hu, Peter Koos, Steven V. Ley |
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| Přispěvatelé: | School of Physical and Mathematical Sciences |
| Rok vydání: | 2012 |
| Předmět: |
Ethylene
Chemistry Aryl Organic Chemistry Flow chemistry Chemistry::Physical chemistry::Catalysis [Science] Catalysis Styrene Inorganic Chemistry chemistry.chemical_compound Chemistry::Organic chemistry::Organic synthesis [Science] Heck reaction Organic chemistry Physical and Theoretical Chemistry Selectivity Hydroformylation |
| Zdroj: | ChemCatChem. 5:159-172 |
| ISSN: | 1867-3880 |
| Popis: | Two tandem flow chemistry processes have been developed. A single palladium-catalysed Heck reaction with ethylene gas provides an efficient synthesis for functionalised styrenes. Through further elaboration the catalyst becomes multi-functional and performs a second Heck reaction providing a single continuous process for the synthesis of unsymmetrical stilbenes. In addition, the continuous, rhodium-catalysed, hydroformylation of styrene derivatives with syngas affords branched aldehydes with good selectivity. Incorporation of an in-line aqueous wash and liquid–liquid separation allowed for the ethylene Heck reaction to be telescoped into the hydroformylation step such that a single flow synthesis of branched aldehydes directly from aryl iodides was achieved. The tube-in-tube semi-permeable membrane-based gas reactor and liquid–liquid separator both play an essential role in enabling these telescoped flow processes. MOE (Min. of Education, S’pore) |
| Databáze: | OpenAIRE |
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