Water deprivation-induced oral self-administration of cocaine in the Lewis rat: evidence for locomotor effects but not reinforcement
| Autor: | Bell Sm, Peter B. Silverman, Richard A. Meisch, Mitchell J. Macenski |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Reinforcement Schedule Clinical Biochemistry Self Administration Stimulus (physiology) Pharmacology Motor Activity Toxicology Biochemistry Locomotor activity Behavioral Neuroscience Cocaine Oral administration Internal medicine medicine Lewis rats Animals Motor activity Reinforcement Biological Psychiatry Water Deprivation Alkaloid Rats Endocrinology Rats Inbred Lew Conditioning Operant Psychology Self-administration Reinforcement Psychology |
| Zdroj: | Pharmacology, biochemistry, and behavior. 45(3) |
| ISSN: | 0091-3057 |
| Popis: | Oral cocaine self-administration was studied in water-deprived Lewis rats. Liquid was available to rats only during daily 90-min sessions, in chambers equipped with spouts that delivered precise volumes of liquid following completion of lever-press responses. Blocks of training and testing sessions were alternately carried out during which increasing cocaine concentrations were presented: 0.0, 0.0125, 0.025, 0.05, 0.1, 0.2, 0.282, and 0.4 mg/ml. Although high cocaine intakes (23.3-33.0 mg/kg) were obtained, neither avoidance nor preference for cocaine developed. Subsequently, fixed-ratio size was increased, and then distinctive stimulus lights were correlated with each liquid. One rat showed a preference for water following these changes, but two rats continued to show no preference. To determine if the amounts of cocaine self-administered had behavioral effects, locomotor activity tests were run immediately following self-administration sessions. Locomotor activity was substantially higher following cocaine self-administration than following water self-administration. These results demonstrate that the cocaine intakes reached under the present conditions did produce locomotor, but not reinforcing, effects. |
| Databáze: | OpenAIRE |
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