Evidence for an association between hairy cell leukemia and renal cell and colorectal carcinoma
| Autor: | Bendt Nielsen, Inger Braide, Hans Hasselbalch |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology Skin Neoplasms Colorectal cancer Pancytopenia Gastroenterology Renal cell carcinoma Internal medicine medicine Carcinoma Humans Hairy cell leukemia Aged Retrospective Studies Leukemia Hairy Cell Epithelioma business.industry Cancer Interferon-alpha Prostatic Neoplasms Middle Aged medicine.disease Kidney Neoplasms Oncology Carcinoma Basal Cell Clear cell carcinoma Colonic Neoplasms Adenocarcinoma Female Facial Neoplasms business |
| Zdroj: | Cancer. 70(8) |
| ISSN: | 0008-543X |
| Popis: | Background. Hairy cell leukemia (HCL) has been associated with several disease states. In this study, a possible association is reported between HCL and renal cell carcinoma (RCC) and colorectal carcinoma (CRC). Methods. A retrospective study of the case records of 50 patients with HCL in a study of a-interferon (a-IFN) treatment of HCL. Results. Three of 50 patients with HCL studied had RCC, and 2 of these also had CRC. In addition, two other patients had CRC. The other malignant lesions developed either before or after the diagnosis of HCL. In all patients, the HCL responded to a-interferon (a-IFN), but in four patients, the second lesion was diagnosed during IFN treatment. Conclusions. These findings could indicate that IFN does not correct a possible common basic etiologic defect and shows that even early CRC and RCC do not respond to the IFN doses administered. These findings should be considered in future trials of IFN treatment of these diseases. The authors also recommend a reevaluation of the frequency of second malignant lesions in HCL; this may be important particularly with the increased survival in patients with HCL who receive a-IFN treatment. Cancer 1992: 702087-2090. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text