Renal disease in chronic arthritis of childhood. A study of urinary N-acetyl-beta-glucosaminidase and beta 2-microglobulin excretion
Autor: | Peter N. Malleson, Marguerite Mahy, Gillian Lockitch, Ross E. Petty, Murray J. Mackinnon |
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Rok vydání: | 1990 |
Předmět: |
Adult
Male medicine.medical_specialty Adolescent Urinary system Immunology Arthritis Disease Gastroenterology Excretion Rheumatology Internal medicine Acetylglucosaminidase medicine Immunology and Allergy Humans Pharmacology (medical) Child Proteinuria business.industry Beta-2 microglobulin Incidence medicine.disease Creatine Endocrinology Child Preschool Chronic Disease Hemoglobinuria Female Kidney Diseases medicine.symptom business beta 2-Microglobulin Juvenile rheumatoid arthritis Biomarkers |
Zdroj: | Arthritis and rheumatism. 33(10) |
ISSN: | 0004-3591 |
Popis: | Urinalyses of randomly obtained samples from children with various types of chronic arthritis revealed proteinuria in 2.3% of patients, hemoglobinuria in 3.5%, erythrocyturia in 4.1%, and leukocyturia in 5.3%; these frequencies are within the range found by screening school children. However, raised urinary levels of N-acetyl-beta-glucosaminidase and/or beta 2-microglobulin (both sensitive measures of renal tubular damage) were found more frequently in children with chronic arthritis than in controls (P less than 0.0001). Abnormalities of either N-acetyl-beta-glucosaminidase or beta 2-microglobulin excretion were associated with active arthritis as measured by physician global estimate of disease activity, with a polyarticular onset of juvenile rheumatoid arthritis, and with the use of slow-acting antirheumatic drugs or the concurrent use of more than 1 nonsteroidal antiinflamtory drug. Abnormal renal tubular function appears to be common in chronic arthritis of childhood. The long-term consequences of this abnormality remain to be elucidated. |
Databáze: | OpenAIRE |
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