Megathrombocytopenia Associated with Glomerulonephritis, Deafness and Aortic Cystic Medianecrosis
| Autor: | Aage Videbæk, O. Behnke, Mogens Sandbjerg Hansen, N. Tinggaard Pedersen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Blood Platelets Male Pathology medicine.medical_specialty Erythrocytes Necrosis Adolescent Platelet Aggregation Platelet aggregation Hearing Loss Sensorineural Aortic Diseases Sensorineural deafness Glomerulonephritis medicine.artery Ascending aorta Leukocytes medicine Humans Platelet Aorta Uremia business.industry Syndrome Hematology medicine.disease Thrombocytopenia Blood Cell Count Giant platelets Aortic Valve Female medicine.symptom business Megakaryocytes |
| Zdroj: | Scandinavian Journal of Haematology. 21:197-205 |
| ISSN: | 0036-553X |
| Popis: | Macrothrombocytopenia associated with glomerulonephritis and deafness has only been reported in a few patients since it was first described in 1972. We present a patient with macrothrombocytopenia, glomerulonephritis, progressive uraemia and progressive sensorineural deafness associated with cystic medianecrosis of the ascending aorta and malformation of the aortic valves. The patient had consistently low platelet counts but no clinical signs of a defect haemostasis. The giant platelets were characterized by their size, averaging 11 micron in diameter, elaborate maze-like membrane formations, abundance of microtubules, and the total absence of very dense granules. |
| Databáze: | OpenAIRE |
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