Pallidal substrate of morphine-induced locomotion
| Autor: | Yannis Anagnostakis, Yannis Krikos, Christina Spyraki |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Morphine hydrochloride Receptors Opioid mu (+)-Naloxone Motor Activity Globus Pallidus Locomotor activity Catheterization Internal medicine medicine Animals Pharmacology (medical) Habituation Psychophysiologic Saline Biological Psychiatry Pharmacology Dose-Response Relationship Drug Morphine Chemistry Naloxone Substrate (chemistry) Rats Inbred Strains Rats Psychiatry and Mental health Globus pallidus Endocrinology Neurology Anesthesia Microinjections Receptors Opioid Neurology (clinical) medicine.drug |
| Zdroj: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2(1) |
| ISSN: | 0924-977X |
| Popis: | Bilateral microinjections of morphine hydrochloride (5.0; 7.5; 10.0 micrograms/0.5 microliters/side) or saline were infused into 3 different regions (dorsal, medial, ventral) of the rat globus pallidus, to examine their effects on locomotor activity. Locomotor activity of each rat was measured 45 min before and 90 min after saline or morphine pallidal microinjections. Morphine induced a dose-dependent increase in locomotion. This increase in locomotion was also significantly different between the 3 pallidal regions. Pretreatment with naloxone (1 mg/kg, sc) inhibited the morphine (7.5 micrograms) hyperlocomotion elicited from all three pallidal areas. The results suggest that the entire pallidum serves as substrate of morphine hyperlocomotion mediated by opiate receptors. |
| Databáze: | OpenAIRE |
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