Red blood cell deformability is reduced in homozygous sickle cell disease patients with leg ulcers
| Autor: | Andre S. Bowers, Walworth W. Duncan, D.J. Pepple |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythrocytes Physiology Cross-sectional study Cell Anemia Sickle Cell 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Erythrocyte Deformability Physiology (medical) Statistical significance Internal medicine medicine Humans Erythrocyte deformability Prospective Studies Prospective cohort study Hematology Red Cell business.industry Leg Ulcer Surgery Red blood cell Cross-Sectional Studies medicine.anatomical_structure Female Cardiology and Cardiovascular Medicine business 030215 immunology |
| Zdroj: | Clinical Hemorheology and Microcirculation. 64:199-204 |
| ISSN: | 1875-8622 1386-0291 |
| Popis: | Previous reports differ as to whether a decreased elongation index (EI), a proxy for red blood cell (RBC) deformability, is associated with leg ulcers (LU) in people with homozygous sickle cell disease (SCD). We sought to determine whether erythrocyte deformability (ED) and haematological indices were associated with the presence of LU in patients with SCD. The study design was cross-sectional. Twenty-seven patients with LU and 23 with no history of ulceration were recruited into the study. A laser assisted rotational red cell analyzer was used in the determination of the EI. Haematological indices were determined using a CELL-DYN Ruby haematology analyzer. Data were normally distributed and presented as means±SD. Two-sample t-test was used to test for associations between haemorheological variables in SCD patients with and without LU. Statistical significance was taken as p < 0.05. The EI was significantly lower in the group with ulcers (0.30±0.07 vs. 0.35±0.07, p = 0.02). Haematological indices were comparable in patients with and without LU. Erythrocyte deformability, but not haematological indices, was associated with LU in patients with SCD. |
| Databáze: | OpenAIRE |
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