Multitarget Stool DNA Test Performance in an Average-Risk Colorectal Cancer Screening Population
| Autor: | Linda J.W. Bosch, Kathleen L.J. Daenen, Gerrit A. Meijer, Barry M. Berger, Michael J. Domanico, S.T. van Turenhout, Veerle M.H. Coupé, Sandra Mongera, Cjj Mulder, Graham P. Lidgard, E. Dekker, Esther M. Stoop, T. R. de Wijkerslooth, M. van Engeland, Beatriz Carvalho, Ernst J. Kuipers, Christian Rausch, Veerle Melotte |
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| Přispěvatelé: | Gastroenterology & Hepatology, Gastroenterology and Hepatology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Quality of Care, AGEM - Re-generation and cancer of the digestive system, Pathology, CCA - Imaging and biomarkers, Epidemiology and Data Science, APH - Methodology, Pathologie, RS: GROW - R2 - Basic and Translational Cancer Biology, RS: GROW - School for Oncology and Reproduction |
| Rok vydání: | 2019 |
| Předmět: |
BIOMARKER
Male Colorectal cancer IMPACT Colonoscopy Muscle Proteins PROGRESSION Bone Morphogenetic Protein 3 medicine.disease_cause Gastroenterology Feces Hemoglobins 0302 clinical medicine Medicine Early Detection of Cancer education.field_of_study medicine.diagnostic_test Immunochemistry METHYLATION Middle Aged 030220 oncology & carcinogenesis Biomarker (medicine) 030211 gastroenterology & hepatology Female KRAS Colorectal Neoplasms Adenoma medicine.medical_specialty Colon Population Colonic Polyps Nerve Tissue Proteins Article Proto-Oncogene Proteins p21(ras) 03 medical and health sciences SDG 3 - Good Health and Well-being Internal medicine Humans Stool dna education Aged Hepatology business.industry Stool test MORTALITY DNA medicine.disease business |
| Zdroj: | American Journal of Gastroenterology, 114(12), 1909-1918. Springer Nature The American Journal of Gastroenterology American journal of gastroenterology, 114(12), 1909-1918. Springer Nature American Journal of Gastroenterology, 114(12), 1909-1918. Nature Publishing Group Bosch, L J W, Melotte, V, Mongera, S, Daenen, K L J, Coupé, V M H, van Turenhout, S T, Stoop, E M, de Wijkerslooth, T R, Mulder, C J J, Rausch, C, Kuipers, E J, Dekker, E, Domanico, M J, Lidgard, G P, Berger, B M, van Engeland, M, Carvalho, B & Meijer, G A 2019, ' Multitarget Stool DNA Test Performance in an Average-Risk Colorectal Cancer Screening Population ', American Journal of Gastroenterology, vol. 114, no. 12, pp. 1909-1918 . https://doi.org/10.14309/ajg.0000000000000445 |
| ISSN: | 0002-9270 |
| DOI: | 10.14309/ajg.0000000000000445 |
| Popis: | INTRODUCTION: We set out to evaluate the performance of a multitarget stool DNA (MT-sDNA) in an average-risk colonoscopy-controlled colorectal cancer (CRC) screening population. MT-sDNA stool test results were evaluated against fecal immunochemical test (FIT) results for the detection of different lesions, including molecularly defined high-risk adenomas and several other tumor characteristics.METHODS: Whole stool samples (n = 1,047) were prospectively collected and subjected to an MT-sDNA test, which tests for KRAS mutations, NDRG4 and BMP3 promoter methylation, and hemoglobin. Results for detecting CRC (n = 7), advanced precancerous lesions (advanced adenoma [AA] and advanced serrated polyps; n = 119), and non-AAs (n = 191) were compared with those of FIT alone (thresholds of 50, 75, and 100 hemoglobin/mL). AAs with high risk of progression were defined by the presence of specific DNA copy number events as measured by low-pass whole genome sequencing.RESULTS: The MT-sDNA test was more sensitive than FIT alone in detecting advanced precancerous lesions (46% (55/119) vs 27% (32/119), respectively, PDISCUSSION: In an average-risk screening population, the MT-sDNA test has an increased sensitivity for detecting advanced precancerous lesions compared with FIT alone. AAs with a high risk of progression were not detected with significantly higher sensitivity by MT-sDNA or FIT. |
| Databáze: | OpenAIRE |
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