Secretory ribonuclease genes and pseudogenes in true ruminants
| Autor: | Adriana Furia, Jaap J. Beintema, Reinhard G. Kleineidam, N. van der Munnik, Heleen J. Breukelman |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
RNase P
animal diseases Pseudogene Molecular Sequence Data Phylogenetics biology.animal Sequence Homology Nucleic Acid Endoribonucleases Genetics Coding region Animals Ribonuclease Amino Acid Sequence Gene Phylogeny Artiodactyla Sheep biology Base Sequence Sequence Homology Amino Acid Deer Brain General Medicine Ribonuclease Pancreatic Roe deer Genes biology.protein Pancreatic ribonuclease Cattle Sequence Alignment Pseudogenes |
| Zdroj: | Gene. 212(2) |
| ISSN: | 0378-1119 |
| Popis: | Mammalian pancreatic ribonucleases (RNase) form a family of extensively studied homologous proteins. Phylogenetic analyses, based on the primary structures of these enzymes, indicated that the presence of three homologous enzymes (pancreatic, seminal and brain ribonucleases) in the bovine species is due to gene duplication events, which occurred during the evolution of ancestral ruminants. In this paper the sequences are reported of the coding regions of the orthologues of the three bovine secretory ribonucleases in hog deer and roe deer, two deer species belonging to two different subfamilies of the family Cervidae. The sequences of the 3' untranslated regions of the three different secretory RNase genes of these two deer species and giraffe are also presented. Comparison of these and previously determined sequences of ruminant ribonucleases showed that the brain-type enzymes of giraffe and these deer species exhibit variations in their C-terminal extensions. The seminal-type genes of giraffe, hog deer and roe deer show all the features of pseudogenes. Phylogenetic analyses, based on the complete coding regions and parts of the 3' untranslated regions of the three different secretory ribonuclease genes of ox, sheep, giraffe and the two deer species, show that pancreatic, seminal- and brain-type RNases form three separate groups. |
| Databáze: | OpenAIRE |
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