Destruction of articular cartilage by arthritic synovium in vitro: mechanism of breakdown and effect of indomethacin and prednisolone
| Autor: | John Panagides, Adolph E. Sloboda, Mary Jane Landes |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
musculoskeletal diseases
Cartilage Articular Male medicine.medical_specialty Hydrocortisone Antimetabolites Immunology Indomethacin Arthritis Toxicology Organ Culture Techniques Internal medicine Culture Techniques medicine Animals Pharmacology (medical) Secretion Pharmacology Chemistry Cartilage Synovial Membrane Proteolytic enzymes Hydrogen-Ion Concentration musculoskeletal system medicine.disease Arthritis Experimental In vitro Culture Media carbohydrates (lipids) medicine.anatomical_structure Endocrinology Biochemistry Macroglobulins Prednisolone Calcium Rabbits medicine.drug Peptide Hydrolases |
| Zdroj: | Agents and actions. 10(1 Pt 2) |
| ISSN: | 0065-4299 |
| Popis: | Arthritic synovial tissue when cultured with normal articular cartilage induces a breakdown of articular cartilage proteoglycans. No collagen breakdown occurs unless the macroglobulins are inactivated by pretreatment with acid. Proteoglycan breakdown is most likely due to the continuous secretion of hydrolases by the synovium. A proteolytic enzyme has been found in the culture medium which has a pH optimum around 7.6, and is Ca++ dependent. Both indomethacin and hydrocortisone are inhibitors of proteoglycan breakdown. |
| Databáze: | OpenAIRE |
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