Exosomes: new molecular targets of diseases
| Autor: | Zhigang Zhou, Johnson Rajasingh, Buddhadeb Dawn, Saheli Samanta, Sheeja Rajasingh, Nicholas Drosos |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Heart Diseases Cell Review Article Exosomes Extracellular vesicles 03 medical and health sciences Neoplasms microRNA medicine Animals Humans Pharmacology (medical) Enzyme Inhibitors Inflammation Pharmacology Drug Carriers Messenger RNA Chemistry Liver Diseases Immunogenicity Gene Transfer Techniques Neurodegenerative Diseases General Medicine Microvesicles Cell biology 030104 developmental biology medicine.anatomical_structure Molecular targets Biogenesis |
| Zdroj: | Acta Pharmacologica Sinica. 39:501-513 |
| ISSN: | 1745-7254 1671-4083 |
| Popis: | Extracellular vesicles (EVs) comprise apoptotic bodies, microvesicles and exosomes, and they perform as key regulators in cell-to-cell communication in normal as well as diseased states. EVs contain natural cargo molecules, such as miRNA, mRNA and proteins, and transfer these functional cargos to neighboring cells or more distant cells through circulation. These functionally active molecules then affect distinct signaling cascades. The message conveyed to the recipient cells is dependent upon the composition of the EV, which is determined by the parent cell and the EV biogenesis. Because of their properties such as increased stability in circulation, biocompatibility, low immunogenicity and toxicity, EVs have drawn attention as attractive delivery systems for therapeutics. This review focuses on the functional use of exosomes in therapy and the potential advantages and challenges in using exosomes for therapeutic purposes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink