Pharmacodynamic effects of suvorexant and zolpidem on EEG during sleep in healthy subjects
| Autor: | Arie Struyk, Cynthia Gargano, Junshui Ma, David Mayleben, S. Aubrey Stoch, Vladimir Svetnik, Melissa Drexel |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Zolpidem Pyridines Polysomnography Bedtime Non-rapid eye movement sleep 03 medical and health sciences 0302 clinical medicine Double-Blind Method mental disorders medicine Insomnia Humans Hypnotics and Sedatives Pharmacology (medical) Biological Psychiatry Aged Pharmacology Cross-Over Studies medicine.diagnostic_test business.industry musculoskeletal neural and ocular physiology Suvorexant Electroencephalography Azepines Middle Aged Triazoles Sleep in non-human animals Healthy Volunteers Psychiatry and Mental health 030104 developmental biology Neurology Anesthesia Orexin Receptor Antagonists Neurology (clinical) medicine.symptom Sleep onset Sleep business psychological phenomena and processes 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European Neuropsychopharmacology. 26:1649-1656 |
| ISSN: | 0924-977X |
| Popis: | The objective of this study was to evaluate sleep electrophysiology in healthy subjects after bedtime administration of therapeutic doses of two insomnia treatments - the orexin receptor antagonist suvorexant or the GABAergic agonist zolpidem. Eighteen healthy men received single bedtime doses of suvorexant 20mg, zolpidem 10mg, or placebo in a double-blinded, randomized, balanced 3-period crossover study. EEG power spectral densities during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep were recorded in a polysomnography (PSG) laboratory using a 19-lead EEG recording array. Spectral density was analyzed for each lead for frequencies between 1-32Hz. During NREM and REM sleep, zolpidem treatment reduced spectral density across theta and alpha frequency bands in all leads. In contrast, suvorexant had no significant effects on spectral density in any frequency band during NREM sleep, and modestly increased spectral density in the theta frequency band during REM sleep. Although the study was not designed to detect effects on PSG sleep endpoints in healthy subjects, both suvorexant and zolpidem increased mean total sleep time and sleep efficiency. Zolpidem reduced latency to persistent sleep whereas suvorexant did not. Suvorexant decreased wake after sleep onset, whereas zolpidem did not. These findings suggest that EEG power spectral density profile after administration of suvorexant in healthy subjects more closely approximates placebo sleep physiology than after zolpidem treatment. |
| Databáze: | OpenAIRE |
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