Impact of Mitral Regurgitation on the Flow in a Model of a Left Ventricle

Autor: Ahmed Darwish, Chloé Papolla, Lyes Kadem, Régis Rieu
Přispěvatelé: Aix Marseille Université (AMU), Laboratoire de Biomécanique Appliquée (LBA UMR T24), Aix Marseille Université (AMU)-Université Gustave Eiffel, Concordia University [Montreal], Hôpital Nord [CHU - APHM], Kephalios
Jazyk: angličtina
Rok vydání: 2020
Předmět:
medicine.medical_specialty
Heart Ventricles
[SDV]Life Sciences [q-bio]
0206 medical engineering
Biomedical Engineering
Hemodynamics
02 engineering and technology
030204 cardiovascular system & hematology
In vitrostudy
Ventricular Function
Left
03 medical and health sciences
0302 clinical medicine
Mitral valve
Internal medicine
medicine
Humans
In vitro study
Computer Simulation
Systole
ComputingMilieux_MISCELLANEOUS
Mitral regurgitation
High prevalence
business.industry
Models
Cardiovascular
Mitral Valve Insufficiency
[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph]
medicine.disease
020601 biomedical engineering
Particle image velocimetry
Biomechanical Phenomena
Left ventricle flow
Mitral valveregurgitation
medicine.anatomical_structure
Ventricle
Cardiology
Mitral Valve
[SDV.IB]Life Sciences [q-bio]/Bioengineering
Viscous energydissipation
Rheology
Cardiology and Cardiovascular Medicine
Mitral valve regurgitation
business
Zdroj: Cardiovascular Engineering and Technology
Cardiovascular Engineering and Technology, Springer, 2020, 11 (6), pp.708-718. ⟨10.1007/s13239-020-00490-y⟩
ISSN: 1869-408X
1869-4098
DOI: 10.1007/s13239-020-00490-y⟩
Popis: International audience; Mitral regurgitation (MR) is the second mostcommon valve disease in industrialized countries. Despite itshigh prevalence, little is known about its impact on the flowdynamics in the left ventricle (LV). Because of the interde-pendence between valvular function and hemodynamics inthe heart chambers, an exploration of the dynamics in the LVcould lead to a diagnosis of MR. Thisin vitrostudy aimed todevelop an advanced left heart simulator capable of repro-ducing several conditions of MR and to evaluate their impacton the LV flow dynamics in terms of flow structures andviscous energy dissipation (VED).Methods—A simulator, previously developed to test mechan-ical and biological valves, was upgraded with an originalanatomically-shaped mitral valve made from a hydrogel. Thevalve can be used in healthy or pathological configurations.The nature and severity of the disease was controlled byapplying specific strain to the chordae. In this study, inaddition to a healthy condition, two different severities ofMR were investigated: moderate MR and severe MR. Planartime-resolved particle image velocimetry measurements wereperformed in order to evaluate the velocity field in the LVand the VED induced by each condition.Results—Our results showed that MR led to flow distur-bances in the LV that were characterized by an increase inmitral inflow velocity and by elevated values of VED.Interestingly VED increased in proportion to the severityof MR and with a dissipation predominating during systole.Conclusion—Considering these results, the introduction ofnew parameters based on LV VED could provide crucialinformation regarding the coupling between the mitral valveand the LV and allow for a better stratification of patientswith
Databáze: OpenAIRE
Externí odkaz: