Regulation of SATB1 during thymocyte development by TCR signaling
| Autor: | Dil Afroz Sultana, Jyoti Misra-Sen, Kamalvishnu P. Gottimukkala, Archna Sharma, Indumathi Patta, Sanjeev Galande, Rahul Jangid |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
CD4-Positive T-Lymphocytes Chromatin Immunoprecipitation T cell Cellular differentiation Cell Adhesion Molecules Neuronal Immunology Immunoblotting Receptors Antigen T-Cell GATA3 Transcription Factor Biology Article 03 medical and health sciences Mice medicine Animals Molecular Biology Regulation of gene expression Thymocytes Gene Expression Profiling T-cell receptor GATA3 Cell Differentiation T lymphocyte Flow Cytometry Cell biology Mice Inbred C57BL Thymocyte 030104 developmental biology medicine.anatomical_structure Gene Expression Regulation Cancer research Transcriptome CD8 Signal Transduction |
| Zdroj: | Molecular immunology. 77 |
| ISSN: | 1872-9142 |
| Popis: | Tlymphocyte development and differentiation is a multi-step process that begins in the thymus and completed in the periphery. Sequential development of thymocytes is dependent on T cell receptor (TCR) signaling and an array of transcription factors. In this study we show that special 00AT-rich binding protein 1 (SATB1), a T lineage-enriched chromatin organizer and regulator, is induced in response to TCR signaling during early thymocyte development. SATB1 expression profile coincides with T lineage commitment and upregulation of SATB1 correlates with positive selection of thymocytes. CD4 thymocytes exhibit a characteristic bimodal expression pattern that corresponds to immature and mature CD4 thymocytes. We also demonstrate that GATA3, the key transcriptional regulator of αβ T cells positively regulates SATB1 expression in thymocytes suggesting an important role for SATB1 during T cell development. |
| Databáze: | OpenAIRE |
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