3D DXA Hip Differences in Patients with Acromegaly or Adult Growth Hormone Deficiency

Autor: Esther Ubago-Guisado, Manuel Muñoz-Torres, Beatriz García-Fontana, Luis Gracia-Marco, Antonia García-Martín, Sheila González-Salvatierra, Jose J. Gil-Cosano
Přispěvatelé: [Gracia-Marco,L, Ubago-Guisado,E, Gil-Cosano,JJ] PROFITH 'PROmoting FITness and Health Through Physical Activity' Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain. [Gracia-Marco,L, Ubago-Guisado,E] Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain. [Gonzalez-Salvatierra,S, Garcia-Martin,A, Garcia-Fontana,B, Muñoz-Torres,M] Bone Metabolic Unit, Endocrinology and Nutrition Division, University Hospital Clínico San Cecilio, Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain. [Gonzalez-Salvatierra,S, Muñoz-Torres,M] Department of Medicine, University of Granada, Granada, Spain. [Garcia-Martin,A, Muñoz-Torres,M] CIBERFES, Instituto de Salud Carlos III, Madrid, Spain. [Ubago-Guisado,E] Escuela Andaluza de Salud Pública (EASP), Granada, Spain, This research was funded by the Fondo de Investigación Sanitaria (Instituto de Salud Carlos III) with co-financing from FEDER (grant number PI18/01235), and L.G.-M. was funded by the La Caixa Foundation within the Junior Leader fellowship programme (ID 100010434, code LCF/BQ/PR19/11700007)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Cortical bone
Osteoporosis
lcsh:Medicine
Hormona del crecimiento
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
0302 clinical medicine
Information Science::Information Science::Computing Methodologies::Software [Medical Subject Headings]
Adult growth hormone deficiency
bone QCT/microCT
Bone mineral
DXA
0303 health sciences
General Medicine
Skeleton (computer programming)
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings]
Bone QCT/microCT
medicine.anatomical_structure
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Control Groups [Medical Subject Headings]
musculoskeletal diseases
medicine.medical_specialty
Diseases::Musculoskeletal Diseases::Bone Diseases::Bone Diseases
Endocrine::Acromegaly [Medical Subject Headings]
Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Bones of Lower Extremity::Leg Bones::Femur [Medical Subject Headings]
030209 endocrinology & metabolism
Diseases::Musculoskeletal Diseases::Bone Diseases::Bone Diseases
Metabolic::Osteoporosis [Medical Subject Headings]
Acromegalia
Article
03 medical and health sciences
Internal medicine
Acromegaly
medicine
Persons::Persons::Age Groups::Adult [Medical Subject Headings]
Growth hormone
030304 developmental biology
Femoral neck
Absorciometría de fotón
Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Bone Density [Medical Subject Headings]
Trochanter
Bone modelling and remodelling
business.industry
lcsh:R
medicine.disease
bone modelling and remodelling
osteoporosis
Chemicals and Drugs::Hormones
Hormone Substitutes
and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones [Medical Subject Headings]
Endocrinology
Chemicals and Drugs::Hormones
Hormone Substitutes
and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones::Pituitary Hormones
Anterior::Growth Hormone [Medical Subject Headings]
Hueso cortical
Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Bones of Lower Extremity::Leg Bones::Femur::Femur Neck [Medical Subject Headings]
business
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Radiography::Absorptiometry
Photon [Medical Subject Headings]
Zdroj: Journal of Clinical Medicine
Volume 10
Issue 4
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Journal of Clinical Medicine, Vol 10, Iss 657, p 657 (2021)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
ISSN: 2077-0383
DOI: 10.3390/jcm10040657
Popis: The skeleton is regulated by and responds to pituitary hormones, especially when the circulating levels are perturbed in disease. This study aims to analyse the between-group differences in 3D dual-energy X-ray absorptiometry (DXA) parameters at the hip site among patients with acromegaly or adult growth hormone deficiency (AGHD) and a healthy control group. The current cross-sectional study includes data for 67 adults, 20 with acromegaly, 14 with AGHD and 33 healthy controls. We obtained the areal bone mineral density (aBMD) outcomes using DXA and cortical and trabecular parameters using 3D-DXA software (3D-SHAPER). The mean-adjusted 3D-DXA parameters did not differ between acromegaly patients and the controls (p >
0.05)
however, we found cortical bone impairment (−7.3% to −8.4%
effect size (ES) = 0.78) in AGHD patients (p <
0.05). Differences in the cortical bone parameters were more evident when comparing AGHD patients (−8.5% to −16.2%
ES = 1.22 to 1.24) with acromegaly patients (p <
0.05). In brief, the 3D mapping highlighted the trochanter as the site with greater cortical bone differences between acromegaly patients and the controls. Overall, AGHD patients displayed lower cortical parameters at the trochanter, femoral neck and intertrochanter compared to the controls and acromegaly patients. To sum up, 3D-DXA provided useful information about the characteristics of bone involvement in growth hormone (GH)-related disorders. Patients with AGHD showed distinct involvement of the cortical structure.
Databáze: OpenAIRE
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