Characteristics and outcome of breast cancer-related microangiopathic haemolytic anaemia: a multicentre study
| Autor: | Paul Coppo, François-Clément Bidard, Anne Patsouris, Marion Alhenc-Gelas, Marion Lavigne, Meriem Mokdad-Adi, Delphine Loirat, Lounes Djerroudi, Christelle Levy, Sylvain Ladoire, Josselin Annic, Isabelle Desmoulins, Luc Cabel, Suzette Delaloge, Florence Dalenc, Perrine Vuagnat, Frédérique Berger, Elise Deluche, Nelly Firmin, Jean-Yves Pierga, Pierre-Etienne Heudel, Jean-Sebastien Frenel, Coraline Dubot |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Anemia Hemolytic Survival Bevacizumab Breast Neoplasms 030204 cardiovascular system & hematology Prognostic factors lcsh:RC254-282 Gastroenterology Severity of Illness Index 03 medical and health sciences Breast cancer 0302 clinical medicine Internal medicine medicine Biomarkers Tumor Humans Neoplasm Staging Cytopenia business.industry Area under the curve Cancer Disease Management lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Prognosis Survival Analysis Gemcitabine Schistocyte Phenotype 030220 oncology & carcinogenesis Area Under Curve Female Disease Susceptibility France Neoplasm Grading business Invasive Lobular Breast Carcinoma Research Article Microangiopathic haemolytic anaemia medicine.drug |
| Zdroj: | Breast Cancer Research : BCR Breast Cancer Research, Vol 23, Iss 1, Pp 1-10 (2021) |
| ISSN: | 1465-542X |
| Popis: | Background Cancer-related microangiopathic haemolytic anaemia (MAHA) is a rare but life-threatening paraneoplastic syndrome. Only single cases or small series have been reported to date. We set up a retrospective multicentre study focusing on breast cancer-related MAHA. Methods Main inclusion criteria were known diagnosis of breast cancer, presence of schistocytes and either low haptoglobin or cytopenia and absence of any causes of MAHA other than breast cancer, including gemcitabine- or bevacizumab-based treatment. Patient characteristics, treatments and outcome were retrieved from digital medical records. Results Individual data from 54 patients with breast cancer-related MAHA were obtained from 7 centres. Twenty-three (44%) patients had a breast tumour with lobular features, and most primary tumours were low grade (grade I/II, N = 39, 75%). ER+/HER2−, HER2+ and triple-negative phenotypes accounted for N = 33 (69%), N = 7 (15%) and N = 8 (17%) cases, respectively. All patients had stage IV cancer at the time of MAHA diagnosis. Median overall survival (OS) was 28 days (range 0–1035; Q1:10, Q3:186). Independent prognostic factors for early death (≤ 28 days) were PS > 2 (OR = 7.0 [1.6; 31.8]), elevated bilirubin (OR = 6.9 [1.1; 42.6]), haemoglobin Conclusions Breast cancer-related MAHA appears to be a new feature of invasive lobular breast carcinoma. Prognostic factors and scores may guide clinical decision-making in this serious but not always fatal condition. |
| Databáze: | OpenAIRE |
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