Role of tumor-associated macrophages and angiogenesis in desmoid-type fibromatosis
| Autor: | Belén Canet, Stefhanie Romero, Eliovel Cabrera, Ana I. Peiró, Allan Gonzalez, Jaume Llauger, Inigo Espinosa, Jaime Prat, Justyna Szafranska, Silvia Bagué, Luis Ortega |
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| Rok vydání: | 2012 |
| Předmět: |
CD31
Adult Male Pathology medicine.medical_specialty Adolescent Genotype Angiogenesis Population Kaplan-Meier Estimate Desmoid type fibromatosis Polymerase Chain Reaction Pathology and Forensic Medicine Young Adult medicine Humans education Molecular Biology beta Catenin Microvessel density Aged Aged 80 and over education.field_of_study Neovascularization Pathologic business.industry Macrophages Fibromatosis Soft tissue Cell Biology General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry Fibromatosis Aggressive Tissue Array Analysis Female business CD163 |
| Zdroj: | Virchows Archiv : an international journal of pathology. 461(2) |
| ISSN: | 1432-2307 |
| Popis: | Desmoid-type fibromatosis (DTF) is a rare soft tissue tumor with fibroblastic features affecting two to four individuals per million population per year. Despite its bland microscopic appearance, the tumor behaves aggressively. Although unable to metastasize, DTF tends to recur and local recurrences in anatomically critical sites can be fatal. Tumor-associated macrophages (TAM) play an important role in tumor development through the activation of angiogenesis, particularly in cases of epithelial malignancies. The aim of this study is to investigate the prognostic significance of TAMs and the number of microvessels in DTF. Tumor macrophages (CD163), microvessel density (CD31), and beta-catenin were investigated on 69 primary DTF cases with follow-up information. CTNNB1 mutations were also studied. High density of tumor macrophages and high number of microvessels were associated with a significantly worse recurrence-free survival (P = 0.03 and P = 0.007, respectively). There was a significant correlation between microvessel density and CD163 macrophages (P = 0.02). Furthermore, combination of high number of tumor macrophages and high microvessel density greatly improved the statistical significance (P = 0.000005). Macrophages and microvessels may play an important role in the biologic behavior of DTF. This finding could help in the clinical management of patients with DTF. |
| Databáze: | OpenAIRE |
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