Impaired lymphocyte blastogenic response in patients with colon adenocarcinoma: effects of disease and age
| Autor: | Martin H. Goldrosen, Tin Han, E. Douglas Holyoke, James Smolev, Okhee Jung |
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| Rok vydání: | 1977 |
| Předmět: |
Male
Lymphocyte Disease Adenocarcinoma In Vitro Techniques Lymphocyte Activation Healthy volunteers medicine Humans In patient Patient group Aged Immunity Cellular business.industry Age Factors General Medicine Middle Aged medicine.anatomical_structure Oncology Immunology Colonic Neoplasms Surgery Colon adenocarcinoma Female Immunocompetence Mitogens business |
| Zdroj: | Journal of surgical oncology. 9(3) |
| ISSN: | 0022-4790 |
| Popis: | The in vitro blastogenic response of 76 patients with colon adenocarcinoma and 29 age-matched normal healthy volunteers was compared. An age-related decline in cellular immunocompetence was observed in both the patient and control group. Within each age interval, the patients' blastogenic responses were lower than the controls' and the rate of decline of the blastogenic response in the patient group was greater in magnitude, suggesting that their disease state also contributed to loss of cellular immunocompetence. Thus, both increasing age and presence of tumor are factors that contribute to the decline the immunocompetence in patients with colon adenocarcinoma. |
| Databáze: | OpenAIRE |
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