Effect of Gongronema latifolium Ethanol Leaf Extract on Gastric Acid Secretion and Cytoprotection in Streptozotocin-induced Diabetic Rats
| Autor: | Eme E. Osim, Chukwuemeka R. Nwokocha, AO Obembe, DE Ikpi, AD Essien, Daniel U. Owu |
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| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty food.ingredient Gongronema Ranitidine Diabetes Mellitus Experimental Gastric Acid food Diabetes mellitus Internal medicine medicine Animals Hypoglycemic Agents Stomach Ulcer Dyspepsia Rats Wistar Plant Extracts business.industry Stomach General Medicine Anti-Ulcer Agents Streptozotocin medicine.disease Cytoprotection Small intestine Rats Apocynaceae Plant Leaves medicine.anatomical_structure Endocrinology Gastric Mucosa Gastric acid Medicine Traditional Secretory Rate business Phytotherapy medicine.drug |
| Zdroj: | West Indian Medical Journal. 61:853-860 |
| ISSN: | 0043-3144 |
| DOI: | 10.7727/wimj.2011.040 |
| Popis: | Objectives: Gongronema latifolium leaves have been used in folklore medicine to manage diabetes mellitus and alleviate dyspepsia. This study aimed to provide a pharmacological basis to the medicinal use of Gongronema latifolium as an antidiabetic and antiulcerogenic agent in diabetes mellitus. Methods: Ethanol extract from the leaf (20 0 mg/kg bodyweight ) of Gongronema latifolium was administered to both streptozotocin-induced diabetic and control groups orally for 14 days. Gastric acid secretion was measured and ulcer was induced using ethanol and four-hour pyloric ligation. Results: The mean bodyweight was significantly lower ( p < 0.01), while the mean weight of the stomach, liver and small intestine to bodyweight ratio was increased significantly ( p < 0.05) in the two diabetic groups compared to control. Extract significantly ( p < 0.01) reduced the blood glucose level similar to the non-diabetic control. Basal and stimulated acid secretion in diabetic control rats was significantly ( p < 0.01) decreased when compared to control. Extract administration increased the stimulated gastric acid secretion to a level significantly ( p < 0.05) higher than control while reduction in gastric secretion by ranitidine was similar compared with control . Gongronema latifolium treatment significantly ( p < 0.05) reduced ulcer scores in both ulcer models and increased mucus weight in the diabetic group . Conclusion: These results suggest that Gongronema latifolium antiulcerative activity is due to its prevention of chemical-induced stomach injury. |
| Databáze: | OpenAIRE |
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