Growth Velocity in Pediatric Bone Marrow Transplantation: Significance of Donor Type and Treatment Factors
| Autor: | Debra Schmidt, Mary Jo Kupst, Anne B Warwick, Kristin Bingen, Lynnette Anderson |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Younger age Adolescent Bone marrow transplantation Graft vs Host Disease chemical and pharmacologic phenomena Pediatrics Growth velocity Child Development Risk Factors immune system diseases Unrelated Donor Neoplasms hemic and lymphatic diseases Internal medicine Pediatric bone marrow transplantation medicine Humans Child Bone Marrow Transplantation Retrospective Studies Oncology (nursing) business.industry Age Factors Infant hemic and immune systems Retrospective cohort study Total body irradiation Tissue Donors Surgery Treatment Outcome surgical procedures operative Child Preschool Female Treatment factors business |
| Zdroj: | Journal of Pediatric Oncology Nursing. 26:377-382 |
| ISSN: | 1532-8457 1043-4542 |
| Popis: | Children who have undergone bone marrow transplantation (BMT) often have decreased growth. Growth is a multifactorial process, and the factors that influence growth after BMT are not completely understood. The authors hypothesized that donor type may be a factor influencing growth. Sixty-five children and adolescents who underwent BMT (32 related matched, 33 unrelated matched) were evaluated. Growth velocity (height standard deviation) was assessed prior to and 2 years following BMT. The results indicated that children and adolescents who underwent unrelated matched transplants had lower growth velocity (P < .059) than those with related matched transplants. Those who received the standard conditioning regimen that included total body irradiation (TBI) had a significantly lower growth velocity (P < .045) than those with chemotherapy-only regimens. Significant correlates of growth velocity included younger age at BMT and pre-BMT growth velocity. Thus, donor type, age at BMT, prior treatment, and BMT conditioning regimens that include TBI may all affect growth post-BMT. Careful monitoring of growth velocity is required for patients who have received an unrelated donor BMT. |
| Databáze: | OpenAIRE |
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