Clinical presentation of chronic traumatic encephalopathy
| Autor: | Robert S. Stern, Ann C. McKee, Neil W. Kowall, Robert C. Cantu, Nathan G. Fritts, Thor D. Stein, Clifford A. Robbins, Andrew E. Budson, Lisa McHale, David O. Riley, Daniel H. Daneshvar, Philip H. Montenigro, Irene Simkin, Victor E. Alvarez, Lee E. Goldstein, Julie Stamm, Christine M. Baugh, Daniel R. Seichepine, Christopher J. Nowinski |
|---|---|
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Neurology. 81:1122-1129 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.0b013e3182a55f7f |
| Popis: | Objective: The goal of this study was to examine the clinical presentation of chronic traumatic encephalopathy (CTE) in neuropathologically confirmed cases. Methods: Thirty-six adult male subjects were selected from all cases of neuropathologically confirmed CTE at the Boston University Center for the Study of Traumatic Encephalopathy brain bank. Subjects were all athletes, had no comorbid neurodegenerative or motor neuron disease, and had next-of-kin informants to provide retrospective reports of the subjects’ histories and clinical presentations. These interviews were conducted blind to the subjects’ neuropathologic findings. Results: A triad of cognitive, behavioral, and mood impairments was common overall, with cognitive deficits reported for almost all subjects. Three subjects were asymptomatic at the time of death. Consistent with earlier case reports of boxers, 2 relatively distinct clinical presentations emerged, with one group whose initial features developed at a younger age and involved behavioral and/or mood disturbance (n 5 22), and another group whose initial presentation developed at an older age and involved cognitive impairment (n 5 11). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|