Pituitary Adrenal Responsiveness to Corticotropin-Releasing Hormone in Chronic Uremic Patients

Autor: Vasiliki Alevisou, Kostas C. Siamopoulos, Mathew Dardamanis, M. Pappas, G. Sferopoulos, Despina Kyriaki
Rok vydání: 1990
Předmět:
Male
endocrine system
medicine.medical_specialty
medicine.medical_treatment
Radioimmunoassay
030232 urology & nephrology
Adrenocorticotropic hormone
Hydrocortisone/blood
Peritoneal dialysis
03 medical and health sciences
Corticotropin-releasing hormone
0302 clinical medicine
Renal Dialysis
Internal medicine
medicine
Humans
030212 general & internal medicine
Adrenocorticotropic Hormone/blood
business.industry
General Medicine
Plasma levels
Middle Aged
medicine.disease
Pituitary-Adrenal System/*physiopathology
Uremia
Endocrinology
Corticotropin-Releasing Hormone/*diagnostic use
Nephrology
Chronic renal failure
Female
Hemodialysis
business
Hypothalamo-Hypophyseal System/*physiopathology
Kidney Failure
Chronic/*physiopathology/therapy
hormones
hormone substitutes
and hormone antagonists
Peritoneal Dialysis
Continuous Ambulatory
Hormone
Zdroj: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis. 10:153-156
ISSN: 1718-4304
0896-8608
DOI: 10.1177/089686089001000206
Popis: We investigated the effect of exogenous ovine corticotropin-releasing hormone (oCRH) on plasma levels of adrenocorticotropic hormone (ACTH) and cortisol in 24 chronic renal failure patients: 8 nondialysis (NDCRF), 8 on hemodialysis (HD), and 8 on continuous ambulatory peritoneal dialysis (CAPD). In all groups the acute administration of oCRH caused a further increase (less pronounced in NDCRF patients) in the already elevated levels of cortisol. Following oCRH administration, plasma ACTH rose significantly in CAPD patients, but there was a blunted response of the hormone in the NDCRF and HD groups. The patterns of the ACTH and cortisol response in the last two groups, resemble those observed in chronic stress. We conclude that the hypothalamic-pituitary-adrenal axis in chronic uremic patients, retains the ability to respond to exogenous oCRH. Patients on CAPD, however, display a better, identical to normal response, which can be due to less chronic stress andlor to the more effective clearance of uremic toxins.
Databáze: OpenAIRE
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