Multicentric squamous cell carcinoma in situ resembling Bowen's disease in cats
| Autor: | K. Helton, K. E. Baer |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
0301 basic medicine
Keratinocytes Male Pathology medicine.medical_specialty Skin Neoplasms 040301 veterinary sciences Bowen's Disease Biology Cat Diseases 0403 veterinary science Diagnosis Differential 03 medical and health sciences Dermis Carcinoma medicine Animals Bowen's disease CATS General Veterinary Carcinoma in situ 04 agricultural and veterinary sciences Anatomy medicine.disease Epithelium 030104 developmental biology medicine.anatomical_structure Carcinoma Squamous Cell Cats Female Differential diagnosis Infiltration (medical) Carcinoma in Situ |
| Zdroj: | Veterinary pathology. 30(6) |
| ISSN: | 0300-9858 |
| Popis: | Multicentric squamous cell carcinoma in situ was studied in 12 cats (eight castrated males and four spayed females). The neoplasms occurred in middle-aged to old (mean age = 12 years) mixed-breed cats with a variety of hair-coat colors. The lesions were found in haired pigmented regions of the skin, including the trunk, limbs, feet, head, and neck, and were unrelated to exposure to sunlight. Lesions occurred at multiple sites in nine cats and at solitary sites in three cats and were from 0.5 cm to 3.0 cm in diameter, irregular, slightly, elevated, plaque-like or papillated, and partially alopecic. Histologically, the lesions consisted of sharply demarcated regions of necoplastic, keratinocytic infiltration of the epidermal and follicular infundibular epithelium. Neoplastic cells were confined to the epithelium without frank invasion of the dermis. Two histologic subclasses of multicentric squamous cell carcinoma in situ were identified, the irregular nonhyperkeratotic type and the verrucous hyperkeratotic type. Three cats also had invasive squamous cell carcinoma adjacent to lesions characteristic of multicentric squamous cell carcinoma in situ. Grossly, these were solitary 2.0–4.0 cm-diameter firm, crusted, crateriform cutancous masses. During follow-up periods of 4 to 20 months (mean follow-up period = 11 months), neoplasms did not recur locally after surgical excision; however, similar lesions developed at new sites in four cats. None of the cats had evidence of metastases. Multicentric squamous cell carcinoma in situ in cats is a biologically premalignant neoplasm histologically similar to Bowen's disease in human beings. |
| Databáze: | OpenAIRE |
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